Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) treatment remains lack of effective chemotherapeutic drugs, therefore, discovering novel anti-HCC drugs is a very attractive and urgent task. In this study, we reported VOSL (volatile oil from Saussurea lappa root) exhibits potent therapeutic effect on SMMC-7721 xenogr...

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Bibliographic Details
Published in:Oncotarget 2016-11, Vol.7 (48), p.79761-79773
Main Authors: Lin, Xuejing, Peng, Zhangxiao, Fu, Xiaohui, Liu, Chunying, Xu, Yang, Ji, Weidan, Fan, Jianhui, Chen, Lei, Fang, Lin, Huang, Yao, Su, Changqing
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell Line, Tumor
Cell Proliferation - drug effects
Hep G2 Cells
Humans
Liver Neoplasms - drug therapy
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Oils, Volatile - isolation & purification
Oils, Volatile - pharmacology
Oils, Volatile - therapeutic use
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Receptor, Epidermal Growth Factor - metabolism
Research Paper
Saussurea - chemistry
Signal Transduction - drug effects
Xenograft Model Antitumor Assays
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Summary:Hepatocellular carcinoma (HCC) treatment remains lack of effective chemotherapeutic drugs, therefore, discovering novel anti-HCC drugs is a very attractive and urgent task. In this study, we reported VOSL (volatile oil from Saussurea lappa root) exhibits potent therapeutic effect on SMMC-7721 xenografts without obvious side effects. In the in vitro experiments, VOSL inhibited HCC cell proliferation by arresting cell cycle at S and G2/M phases, and induced HCC cell apoptosis by activating the Caspase3 pathway. VOSL also decreased the capability of HCC cell migration and invasion through MMP-9 depression. Moreover, mechanistic study indicated that VOSL can act as an epithelial growth factor receptor (EGFR) inhibitor to suppress EGFR activation and then to suppress its downstream MEK/P38 and PI3-K/Akt pathways. These results suggested that VOSL may be a novel anti-HCC drug candidate.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.12962