Hydrogel increases localized transport regions and skin permeability during low frequency ultrasound treatment

Low frequency ultrasound (LFU) enhances skin permeability via the formation of heterogeneous localized transport regions (LTRs). In this work, hydrogels with different zeta potentials were used as the coupling medium for LFU to investigate their contribution to LTR patterns and to the skin penetrati...

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Bibliographic Details
Published in:Scientific reports 2017-03, Vol.7 (1), p.44236-44236, Article 44236
Main Authors: Pereira, Tatiana Aparecida, Ramos, Danielle Nishida, Lopez, Renata F. V.
Format: Article
Language:English
Subjects:
639/925
692/699/4033/1813
Calcein
Doxorubicin
Epidermis
Humanities and Social Sciences
Hydrogels
multidisciplinary
Permeability
Science
Skin
Sodium
Sodium lauryl sulfate
Stratum corneum
Sulfates
Ultrasonic imaging
Ultrasound
Zeta potential
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Summary:Low frequency ultrasound (LFU) enhances skin permeability via the formation of heterogeneous localized transport regions (LTRs). In this work, hydrogels with different zeta potentials were used as the coupling medium for LFU to investigate their contribution to LTR patterns and to the skin penetration of two model drugs, calcein and doxorubicin (DOX). When hydrogels were used, LTRs covering at least a 3-fold greater skin area were observed compared to those resulting from traditional LFU treatment and sodium lauryl sulfate. More LTRs resulted in an enhancement of calcein skin permeation. The zeta potential of the hydrogels affected the skin penetration of the positively charged DOX; the cationic coupling medium decreased the DOX recovered from the viable epidermis by 2.8-fold, whereas the anionic coupling medium increased the DOX accumulation in the stratum corneum by 4.4-fold. Therefore, LFU/hydrogel treatment increases LTRs areas and can target ionized drugs to specific skin layers depending on the zeta potential of the coupling medium.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep44236