Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway

Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1β-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results dem...

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Bibliographic Details
Published in:Oncotarget 2016-12, Vol.7 (50), p.83720-83726
Main Authors: Kong, Pengyu, Chen, Guanghua, Jiang, Anlong, Wang, Yufu, Song, Chengchao, Zhuang, Jinpeng, Xi, Chunyang, Wang, Guangxi, Ji, Ye, Yan, Jinglong
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - pharmacology
Cell Survival - drug effects
Cells, Cultured
Chondrocytes - drug effects
Chondrocytes - immunology
Chondrocytes - metabolism
Dinoprostone - metabolism
Dioxoles - pharmacology
Dose-Response Relationship, Drug
Heme Oxygenase-1 - metabolism
Humans
Interleukin-1beta - pharmacology
Lignans - pharmacology
Matrix Metalloproteinases, Secreted - metabolism
Middle Aged
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
NF-KappaB Inhibitor alpha - metabolism
Nitric Oxide - metabolism
Osteoarthritis, Knee - drug therapy
Osteoarthritis, Knee - genetics
Osteoarthritis, Knee - immunology
Osteoarthritis, Knee - metabolism
Phosphorylation
Research Paper
RNA Interference
Signal Transduction - drug effects
Transcription Factor RelA - metabolism
Transfection
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Summary:Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1β-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1β. Sesamin inhibited MMP1, MMP3, and MMP13 production in IL-1β-stimulated chondrocytes. Sesamin also inhibited IL-1β-induced phosphorylation of NF-κB p65 and IκBα. Meanwhile, sesamin was found to up-regulate the expression of Nrf2 and HO-1. However, Nrf2 siRNA reversed the anti-inflammatory effects of sesamin. In conclusion, our results suggested that sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes by activating Nrf2 signaling pathway.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.13360