Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma

Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased in cancer and favors cell proliferation and survival by permitting calcium influx. In this study, Orai3 was overexpressed in lung adenocarcinoma as compared to their matched non-tumour samp...

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Bibliographic Details
Published in:Oncotarget 2016-12, Vol.7 (49), p.81588-81597
Main Authors: Benzerdjeb, Nazim, Sevestre, Henri, Ahidouch, Ahmed, Ouadid-Ahidouch, Halima
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemistry
Adenocarcinoma - mortality
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Adenocarcinoma of Lung
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Disease-Free Survival
Estrogen Receptor alpha - analysis
Female
Humans
Life Sciences
Logistic Models
Lung Neoplasms - chemistry
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Male
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
Neoplasm Staging
Odds Ratio
ORAI1 Protein - analysis
Pneumonectomy - adverse effects
Pneumonectomy - mortality
Proportional Hazards Models
Research Paper
Risk Factors
Time Factors
Treatment Outcome
Up-Regulation
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Summary:Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased in cancer and favors cell proliferation and survival by permitting calcium influx. In this study, Orai3 was overexpressed in lung adenocarcinoma as compared to their matched non-tumour samples and was associated with tumoural aggressiveness. Moreover, its expression was associated with estrogen receptor alpha (ERα) expression and visceral pleural invasion in multivariate analysis. Furthermore, both the overall survival (OS) median and the metastasis free survival (MFS) median of tumors with high Orai3 expression were lower than in low Orai3 expression regardless of cancer stage (35.01 months vs. 51.11 months for OS and 46.01 months vs. 62.04 months for MFS). In conclusion, Orai3 protein level constitutes an independent prognostic marker in lung adenocarcinoma, and a novel prognostic marker that could help selecting the patients with worst prognosis to be treated with adjuvant chemotherapy in resectable stage.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.13149