The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome

A young woman with Li-Fraumeni syndrome (LFS) was referred to our hospital. On examination, multiple flat neoplasms were detected in addition to semi-pedunculated polyps. Restorative proctocolectomy was performed; one submucosal invasive cancer, two mucosal cancers, and several adenomas with high-gr...

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Bibliographic Details
Published in:Internal Medicine 2017/02/01, Vol.56(3), pp.295-300
Main Authors: Yoshida, Tsukasa, Tajika, Masahiro, Tanaka, Tsutomu, Ishihara, Makoto, Hirayama, Yutaka, Mizuno, Nobumasa, Hara, Kazuo, Hijioka, Susumu, Imaoka, Hiroshi, Hieda, Nobuhiro, Okuno, Nozomi, Kinoshita, Takashi, Bhatia, Vikram, Shimizu, Yasuhiro, Yatabe, Yasushi, Yamao, Kenji, Niwa, Yasumasa
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - diagnostic imaging
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adenoma - diagnosis
Adenoma - diagnostic imaging
Adenoma - pathology
Adenoma - surgery
Adult
Carcinoma
Case Report
Colon
Colonoscopy
colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - diagnostic imaging
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
colorectal polyps
Diagnosis, Differential
Dysplasia
Female
Humans
Internal medicine
Invasiveness
laterally spreading tumor
Li-Fraumeni Syndrome
Mucosa
p53 Protein
Polyps
Staining
TP53
Tumors
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Summary:A young woman with Li-Fraumeni syndrome (LFS) was referred to our hospital. On examination, multiple flat neoplasms were detected in addition to semi-pedunculated polyps. Restorative proctocolectomy was performed; one submucosal invasive cancer, two mucosal cancers, and several adenomas with high-grade dysplasia were detected. On immunohistochemical staining with p53, every part of all neoplasms, even the small adenomas, showed strong positive staining. Multiple flat neoplasms may be characteristic of patients with LFS and may have a much higher risk of rapid progression to invasive carcinomas than sporadic neoplasms. Thus, careful and frequent colonoscopy surveillance may be needed for patients with LFS.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.56.7274