Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and -9

Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due to its high metastatic potential. Naringenin, a bioactive compound identified in several fruits, displays anti-inflammatory and antitumor effects. Furthermore, nar...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2017-02, Vol.13 (2), p.739-744
Main Authors: Chang, Huai-Lu, Chang, Yuh-Ming, Lai, Shih-Chan, Chen, Ke-Min, Wang, Kuan-Chu, Chiu, Tsu-Ting, Chang, Fu-Hsin, Hsu, Li-Sung
Format: Article
Language:English
Subjects:
Apoptosis
Biotechnology
Bladder cancer
Breast cancer
Cancer cells
Care and treatment
Flavonoids
Health aspects
Kinases
Lung cancer
Medical prognosis
Metalloproteins
Metastasis
Mortality
Natural products
Penicillin
Physiological aspects
Polyphenols
Properties
Proteins
Wound healing
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Summary:Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due to its high metastatic potential. Naringenin, a bioactive compound identified in several fruits, displays anti-inflammatory and antitumor effects. Furthermore, naringenin mitigates the migration of several human cancer cell types. However, the effects of naringenin on lung cancer remain unclear. The current study investigated the mechanisms of naringenin on the migration of lung cancer A549 cells. The results indicate that significant alteration in A549 cell proliferation was observed in response to naringenin (0-300 µM) treatment for 24 and 48 h. Furthermore, a dose-dependent migration inhibition of A549 in the presence of naringenin was observed by healing and transwell migration assays. In addition, a zymography assay revealed that naringenin exhibited a concentration-dependent inhibition of matrix metalloproteinase (MMP)-2 and -9 activities. Furthermore, naringenin also inhibited the activities of AKT in a dose-dependent manner. These observations indicated that naringenin inhibited the migration of lung cancer A549 cells through several mechanisms, including the inhibition of AKT activities and reduction of MMP-2 and -9 activities.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2016.3994