Neuroprotection in Neurodegenerative Disease: From Basic Science to Clinical Applications

[...]we remain ignorant of the genesis of the major neurodegenerative diseases in individuals, although the study of gene expression in human groups who are highly susceptible to AD such as those with Down's syndrome is a notable exception. [...]this special issue also illustrates that the mech...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2017-01, Vol.2017 (1), p.2949102-2949102
Main Authors: Monteiro, Marta C., Coleman, Michael D., Hill, Eric J., Prediger, Rui D., Maia, Cristiane S. F.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal cognition
Animals
Anti-Inflammatory Agents - pharmacology
Antioxidants
Complications and side effects
Degeneration
Dosage and administration
Gene expression
Health sciences
Humans
Inflammation - physiopathology
Ischemia
Melatonin
Nervous system
Nervous system agents
Neurodegenerative Diseases - physiopathology
Neuroprotection - drug effects
Neuroprotection - physiology
Neuroprotective Agents - pharmacology
Oxidative stress
Pathogenesis
Rodents
Studies
Citations: Items that cite this one
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Description
Summary:[...]we remain ignorant of the genesis of the major neurodegenerative diseases in individuals, although the study of gene expression in human groups who are highly susceptible to AD such as those with Down's syndrome is a notable exception. [...]this special issue also illustrates that the mechanisms at play in neurodegenerative diseases are clearly multifactorial in terms of their impact on CNS functionality, with contributions from the immune system, antioxidant status, changes in gene expression, and epigenetic impacts on enzymatic function.
ISSN:1942-0900
1942-0994
DOI:10.1155/2017/2949102