Incidence, risk factors and clinical outcomes of acute kidney injury associated with scrub typhus: a retrospective study of 510 consecutive patients in South Korea (2001–2013)

ObjectivesRenal involvement in scrub typhus ranges from simple urinary abnormalities to acute kidney injury (AKI) leading to death. This study evaluated the incidence, predictors and prognosis of AKI associated with scrub typhus according to the RIFLE (risk, injury, failure, loss, end-stage kidney d...

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Bibliographic Details
Published in:BMJ open 2017-03, Vol.7 (3), p.e013882
Main Authors: Hwang, Kyungo, Jang, Ha Nee, Lee, Tae Won, Cho, Hyun Seop, Bae, Eunjin, Chang, Se-Ho, Park, Dong Jun
Format: Article
Language:English
Subjects:
Acute Kidney Injury - epidemiology
Acute Kidney Injury - etiology
Adult
Age Factors
Aged
Classification
Clinical outcomes
Comorbidity
Creatinine
Diabetes
Encephalitis
Female
Fever
Hematuria
Hemoglobin
Hospitalization
Hospitals
Humans
Hypertension
Incidence
Infectious diseases
Intensive Care Units
Kidney - pathology
Kidney - physiopathology
Kidney diseases
Kidney Failure, Chronic - etiology
Laboratories
Male
Medical records
Middle Aged
Patients
Prognosis
Renal Insufficiency, Chronic - complications
Renal Medicine
Republic of Korea - epidemiology
Retrospective Studies
Risk Factors
Scrub Typhus - complications
Scrub Typhus - pathology
Severe acute respiratory syndrome
Statistical analysis
Tropical diseases
Typhus
Urine
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Summary:ObjectivesRenal involvement in scrub typhus ranges from simple urinary abnormalities to acute kidney injury (AKI) leading to death. This study evaluated the incidence, predictors and prognosis of AKI associated with scrub typhus according to the RIFLE (risk, injury, failure, loss, end-stage kidney disease) criteria.MethodsWe retrospectively evaluated the medical records of patients diagnosed with scrub typhus from January 2001 to November 2013 in Gyeongsang National University Hospital.ResultsDuring the study period, 510 patients were diagnosed with scrub typhus and the incidence of AKI was 35.9%. There were 132 (25.9%) patients at risk, 37 (7.3%) with injury and 14 (2.7%) with failure. In comparison with the non-AKI group, the AKI group was older (73.9 vs 63.4 years, p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2016-013882