Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival

Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard applied prognostic markers, including estrogen/progesterone receptor status (ER/...

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Bibliographic Details
Published in:Oncotarget 2017-02, Vol.8 (6), p.9696-9707
Main Authors: Mauland, Karen Klepsland, Wik, Elisabeth, Hoivik, Erling A, Kusonmano, Kanthida, Halle, Mari Kyllesø, Berg, Anna, Haugland, Hans Kristian, Øyan, Anne Margrete, Kalland, Karl-Henning, Stefansson, Ingunn Marie, Akslen, Lars A, Krakstad, Camilla, Trovik, Jone, Werner, Henrica Maria Johanna, Salvesen, Helga Birgitte
Format: Article
Language:English
Subjects:
Aged
Aneuploidy
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Chromosomes, Human, Pair 15
Disease Progression
Endometrial Neoplasms - genetics
Endometrial Neoplasms - mortality
Endometrial Neoplasms - pathology
Female
Flow Cytometry
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local
Neoplasm Staging
Phenotype
Proportional Hazards Models
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Research Paper
Risk Factors
Time Factors
Transcription, Genetic
Transcriptome
Treatment Outcome
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Summary:Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard applied prognostic markers, including estrogen/progesterone receptor status (ER/PR). Also, little is known about aneuploidy-related transcriptional alterations, relevant for understanding its role in EC biology, and as therapeutic target.We included 825 EC patients with available ploidy status and comprehensive clinicopathologic characterization to analyze ploidy as a prognostic marker. For 144 patients, gene expression data were available to explore aneuploidy-related transcriptional alterations.Aneuploidy was associated with high age, FIGO stage and grade, non-endometrioid histology, ER/PR negativity, and poor survival (p-values
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.14201