A novel long noncoding RNA PILRLS promote proliferation through TCL1A by activing MDM2 in Retroperitoneal liposarcoma

It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in retroperitoneal liposarcoma have never been reported. In our study, we found a novel lncRNA PILRLS (Proliferation...

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Bibliographic Details
Published in:Oncotarget 2017-02, Vol.8 (8), p.13971-13978
Main Authors: Shao, Yebo, Zhang, Yong, Hou, Yingyong, Tong, Hanxing, Zhuang, Rongyuan, Ji, Zhengbiao, Wang, Binliang, Zhou, Yuhong, Lu, Weiqi
Format: Article
Language:English
Subjects:
Animals
Blotting, Northern
Blotting, Western
Cell Proliferation
Female
Gene Expression Regulation, Neoplastic - genetics
Heterografts
Humans
Liposarcoma - genetics
Liposarcoma - metabolism
Liposarcoma - pathology
Mice
Mice, Inbred BALB C
Mice, Nude
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-mdm2 - genetics
Proto-Oncogene Proteins c-mdm2 - metabolism
Real-Time Polymerase Chain Reaction
Research Paper
Retroperitoneal Neoplasms - genetics
Retroperitoneal Neoplasms - metabolism
Retroperitoneal Neoplasms - pathology
RNA, Long Noncoding
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Summary:It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in retroperitoneal liposarcoma have never been reported. In our study, we found a novel lncRNA PILRLS (Proliferation Interacting LncRNA in Retroperitoneal Liposarcoma), which as an oncogene significantly overexpressed in retroperitoneal liposarcoma. Functions of PILRLS on tumor progression both in vitro and in vivo have verified in this study which PILRLS knockdown significantly inhibited cell proliferation and colony formation. RNA pull-down assay found PILRLS can specific binding with TCL1A which also regulate the expression level of TCL1A. Our work for the first time demonstrated PILRLS can activating the MDM2 by binding with TCL1A which suppress the P53 pathway to promote the unlimited growth of retroperitoneal Liposarcoma cells. It suggests that PILRLS may be an important targets for retroperitoneal liposarcoma therapy.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.14814