Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells

There is currently a pressing need for alternative the-rapies to liver transplantation. The number of patients waiting for a liver transplant is substantially higher than the number of transplantable donor livers, resulting in a long waiting time and a high waiting list mortality. An extracorporeal...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2017-03, Vol.23 (11), p.1974-1979
Main Authors: Sakiyama, Ryoichi, Blau, Brandon J, Miki, Toshio
Format: Article
Language:English
Subjects:
Biological Therapy - methods
Bioreactors
Cell Differentiation
Clinical Trials as Topic
Hepatocytes - physiology
Humans
Liver Failure - therapy
Liver Transplantation - adverse effects
Liver, Artificial
Minireviews
Pluripotent Stem Cells - physiology
Waiting Lists - mortality
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Summary:There is currently a pressing need for alternative the-rapies to liver transplantation. The number of patients waiting for a liver transplant is substantially higher than the number of transplantable donor livers, resulting in a long waiting time and a high waiting list mortality. An extracorporeal liver support system is one possible approach to overcome this problem. However, the ideal cell source for developing bioartificial liver(BAL) support systems has yet to be determined. Recent advancements in stem cell technology allow researchers to generate highly functional hepatocyte-like cells from human pluripotent stem cells(h PSCs). In this mini-review, we summarize previous clinical trials with different BAL systems, and discuss advantages of and potential obstacles to utilizing h PSC-derived hepatic cells in clinical-scale BAL systems.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v23.i11.1974