Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis

Purpose The aim of this study was to assess whether the intrafollicular cytokine profile in naturally developed follicles is different in women with endometriosis, possibly explaining the lower reproductive outcome in endometriosis patients. Methods A matched case-control study was conducted at a un...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2017-03, Vol.34 (3), p.357-364
Main Authors: Wu, Gengxiang, Bersinger, N. A., Mueller, M. D., von Wolff, M.
Format: Article
Language:English
Subjects:
Adult
Cytokines
Cytokines - blood
Endometriosis
Endometriosis - blood
Endometriosis - pathology
Female
Fertilization in Vitro
Follicles
Follicular Fluid - metabolism
Gynecology
Hormones
Hormones - blood
Human Genetics
Humans
Infertility
Infertility, Female - blood
Infertility, Female - pathology
Medicine
Medicine & Public Health
Oocyte Retrieval - methods
Ovarian Follicle - growth & development
Ovarian Follicle - metabolism
Ovulation Induction - methods
Physiology
Reproductive health
Reproductive Medicine
Reproductive Physiology and Disease
Reproductive Techniques, Assisted
Steroids
Ultrasonic imaging
Womens health
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Summary:Purpose The aim of this study was to assess whether the intrafollicular cytokine profile in naturally developed follicles is different in women with endometriosis, possibly explaining the lower reproductive outcome in endometriosis patients. Methods A matched case-control study was conducted at a university-based infertility and endometriosis centre. The study population included 17 patients with laparoscopically and histologically confirmed endometriosis (rAFS stages II–IV), each undergoing one natural cycle IVF (NC-IVF) treatment cycle between 2013 and 2015, and 17 age-matched NC-IVF women without diagnosed endometriosis (control group). Follicular fluid and serum was collected at the time of follicle aspiration. The concentrations of inflammatory cytokines (IL-1β, IL-6, IL-8, IL-15, IL-18, TNF-α) and hormones (testosterone, estradiol, AMH) were determined in follicular fluid and serum by single or multiplexed immunoassay and compared between both groups. Results In the follicular fluid, IL-1β and IL-6 showed significantly ( P  
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-016-0865-3