Low Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis

Objective. Studies are ongoing to find appropriate low frequency stimulation (LFS) protocol for treatment of epilepsy. The present study aimed at assessing the antiepileptogenesis effects of LFS with the same protocol applied either just before or immediately after kindling stimulations. Method. Thi...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-8
Main Authors: Ghotbeddin, Zohreh, Moazedi, Ahmad Ali, Yadollahpour, Ali, Jalilifar, Mostafa
Format: Article
Language:English
Subjects:
Animals
Brain research
Care and treatment
Convulsions & seizures
Electric stimulation
Electric Stimulation Therapy - methods
Epilepsy
Epilepsy - physiopathology
Epilepsy - therapy
Humans
Kindling, Neurologic
Laboratory animals
Methods
Prevention
Rats
Rats, Wistar
Rodents
Seizures - physiopathology
Seizures - therapy
Studies
Surgery
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Summary:Objective. Studies are ongoing to find appropriate low frequency stimulation (LFS) protocol for treatment of epilepsy. The present study aimed at assessing the antiepileptogenesis effects of LFS with the same protocol applied either just before or immediately after kindling stimulations. Method. This experimental animal study was conducted on adult Wistar rats (200 ± 20 g) randomly divided into kindle (n=7), LFS + Kindle (n=6), and Kindle + LFS groups (n=6). All animals underwent rapid kindling procedure and four packages of LFS (1 Hz) with 5 min interval were applied either immediately before (LFS-K) or after kindling stimulation (K-LFS). The after discharge duration (ADD), daily stages of kindling, and kindling seizure stage and number of stimulations required to reach each stage were compared between the three groups using two-way analysis of variance (ANOVA) followed by Tukey post hoc and one-way ANOVA, and Kruskal-Wallis test, respectively. Results. LFS in both protocols significantly decreased the ADD (p
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/8623743