Susceptibility to Miltefosine in Brazilian Clinical Isolates of Leishmania ( Viannia ) braziliensis

Abstract ( ) is the main causative species of tegumentary leishmaniasis in Brazil. In this study, we evaluated the susceptibility of 16 clinical isolates of ( ) from different regions of Brazil to miltefosine in vitro. Half-maximal inhibitory concentrations of miltefosine varied from 22.9 to 144.2 μ...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2017-01, Vol.96 (3), p.656-659
Main Authors: Espada, Caroline R, Ribeiro-Dias, Fatima, Dorta, Miriam L, Pereira, Ledice Inácia de Araújo, Carvalho, Edgar M de, Machado, Paulo R, Schriefer, Albert, Yokoyama-Yasunaka, Jenicer K U, Coelho, Adriano C, Uliana, Silvia R B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Brazil
Child, Preschool
Drug Resistance
Humans
Inhibitory Concentration 50
Leishmania braziliensis - drug effects
Leishmania braziliensis - isolation & purification
Middle Aged
Phosphorylcholine - analogs & derivatives
Phosphorylcholine - therapeutic use
Young Adult
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Summary:Abstract ( ) is the main causative species of tegumentary leishmaniasis in Brazil. In this study, we evaluated the susceptibility of 16 clinical isolates of ( ) from different regions of Brazil to miltefosine in vitro. Half-maximal inhibitory concentrations of miltefosine varied from 22.9 to 144.2 μM against promastigotes and from 0.3 to 4.2 μM against intracellular amastigotes. No significant differences were found between isolates of different geographical origins. A clear correlation between the EC against promastigotes and amastigotes within each isolate was found. These findings contribute to the evaluation of miltefosine's potential and limitations for the treatment of tegumentary leishmaniasis in Brazil.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.16-0811