Prevalence of and risk factors for osteoporosis and fracture among a male HIV-infected population in the UK

Rates of osteoporosis and fracture may be increased in HIV but there are few UK data. Our aim was to examine the prevalence of and risk factors for osteoporosis and fractures among a homogeneous cohort of well-characterized HIV-infected men. In total, 168 men were recruited, median age 45 years, 37...

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Bibliographic Details
Published in:International journal of STD & AIDS 2014-02, Vol.25 (2), p.113-121
Main Authors: Short, Charlotte-Eve S, Shaw, Simon G, Fisher, Martin J, Walker-Bone, Karen, Gilleece, Yvonne C
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adult
Bone Density
Cross-Sectional Studies
Fractures, Bone - epidemiology
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - epidemiology
Hospitals, Teaching
Humans
Logistic Models
Male
Middle Aged
Osteoporosis - complications
Osteoporosis - epidemiology
Osteoporosis - etiology
Prevalence
Risk Factors
United Kingdom - epidemiology
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Summary:Rates of osteoporosis and fracture may be increased in HIV but there are few UK data. Our aim was to examine the prevalence of and risk factors for osteoporosis and fractures among a homogeneous cohort of well-characterized HIV-infected men. In total, 168 men were recruited, median age 45 years, 37 combination antiretroviral therapy (cART) naïve, 46 with 10 years). All participants provided information on bone health and underwent DEXA scanning. Osteopenia was found in 58% of subjects and osteoporosis in 12%; 14% reported fractures since HIV diagnosis. Number of fractures since HIV diagnosis was significantly increased among those with osteoporosis (OR 3.5, 95% CI 1.2–10.4, p = 0.018). Duration of infection greater than 13 years was significantly associated with osteoporosis. Duration of cART was associated in univariate but not multivariate analyses. Strategies to prevent osteoporosis and fractures in HIV will require attention to viral and lifestyle factors and not just cART.
ISSN:0956-4624
1758-1052
DOI:10.1177/0956462413492714