The role of long non-coding RNAs in nasopharyngeal carcinoma: As systemic review

Recent development of cutting edge research found that long noncoding RNAs (lncRNAs) plays important roles in carcinogenesis and progression. In Southeast Asia and North Africa, nasopharyngeal carcinoma (NPC) is the most common aggressive squamous cell carcinoma. Nasopharyngeal carcinoma is most fre...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget 2017-02, Vol.8 (9), p.16075-16083
Main Authors: He, Rongzhang, Hu, Zheng, Wang, Qingmei, Luo, Weihao, Li, Jia, Duan, Lili, Zhu, Yuan-Shan, Luo, Di-Xian
Format: Article
Language:English
Subjects:
Carcinogenesis - genetics
Carcinoma - genetics
Cell Line, Tumor
Disease Progression
Humans
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - genetics
Prognosis
Review
RNA, Long Noncoding - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent development of cutting edge research found that long noncoding RNAs (lncRNAs) plays important roles in carcinogenesis and progression. In Southeast Asia and North Africa, nasopharyngeal carcinoma (NPC) is the most common aggressive squamous cell carcinoma. Nasopharyngeal carcinoma is most frequently occurring in males. However, nasopharyngeal carcinoma is caused by a combination of several factors as viral, environmental factors, and heredity. Till now, the potential pathway or mechanism of NPC is not well known. In our present review, we strongly emphasized on long noncoding RNAs (lncRNAs) and its significant role in nasopharyngeal carcinoma. It has been showed that lncRNAs regulate the development and progression of different types of cancers, including NPC. In addition, it has been found that chromatin organization, transcriptional and post-transcriptional events are regulated by lncRNAs. Our present review summarizes the roles of lncRNAs in nasopharyngeal carcinoma and provides an overview of the feasibility of lncRNAs as diagnosis, prognosis and potential treatment for NPC patients.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.14211