Role of Versican and ADAMTS-1 in Polycystic Ovary Syndrome

• Published in: Journal of clinical research in pediatric endocrinology 2017-03, Vol.9 (1), p.24-30
• Main Authors: Özler, Sibel, Öztaş, Efser, Tokmak, Aytekin, Ergin, Merve, Kuru Pekcan, Meryem, Gümüş Güler, Başak, Yakut, Halil İbrahim, Yılmaz, Nafiye
• Format: Article
• Language: English
• Subjects: ADAMTS1 Protein - blood; Adolescent; Analysis; Body Mass Index; Enzyme-Linked Immunosorbent Assay; Female; Genetic aspects; Humans; Insulin Resistance; Logistic Models; Multivariate Analysis; Oligomenorrhea - blood; Oligomenorrhea - diagnosis; Original; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - diagnosis; Proteoglycans; Reference Values; Risk Assessment - methods; Risk Assessment - statistics & numerical data; Risk Factors; ROC Curve; Tıp; Versicans - blood; Young Adult
• ISSN: 1308-5727; 1308-5735
• DOI: 10.4274/jcrpe.3414

ADAMTS-1 is a matrix metalloproteinase which cleaves versican in the cumulus oocyte complex under the effect of luteinizing hormone surge in the periovulatory period. Altered levels may have a role in the pathogenesis of polycystic ovary syndrome (PCOS). We aimed to determine the serum versican and ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motif-1) levels in PCOS patients and compare the results with healthy controls. Thirty-eight patients with PCOS and forty healthy controls aged between 15 and 22 years were included in the study. They were sampled according to their basal hormone, serum versican, and ADAMTS-1 levels. Serum versican and ADAMTS-1 levels were measured by enzyme-linked immunosorbent assay. A multivariate logistic regression model was used to identify the independent risk factors of PCOS. Serum versican levels were significantly decreased in the PCOS group when compared with the controls. The best versican cut-off value for PCOS was calculated to be 33.65 with 76.74% sensitivity and 52.94% specificity. Serum versican levels, homeostasis model assessment of insulin resistance index, a Ferriman-Gallwey score higher than 8, and oligomenorrhea were the strongest predictors of PCOS. Serum versican levels were significantly decreased in PCOS patients. Besides, serum ADAMTS-1 and versican levels were significantly and positively correlated with each other. Serum versican levels were significantly decreased in patients with PCOS. This suggests a possible role of versican in ovulatory dysfunction and in the pathogenesis of PCOS.