The first investigation of Wilms' tumour atomic structure-nitrogen and carbon isotopic composition as a novel biomarker for the most individual approach in cancer disease

The paper describes a novel approach to investigating Wilms' tumour (nephroblastoma) biology at the atomic level. Isotope Ratio Mass Spectrometry (IRMS) was used to directly assess the isotope ratios of nitrogen and carbon in 84 Wilms' tumour tissue samples from 28 cases representing the h...

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Bibliographic Details
Published in:Oncotarget 2016-11, Vol.7 (47), p.76726-76734
Main Authors: Taran, Katarzyna, Frączek, Tomasz, Sikora-Szubert, Anita, Sitkiewicz, Anna, Młynarski, Wojciech, Kobos, Józef, Paneth, Piotr
Format: Article
Language:English
Subjects:
Biomarkers
Carbon Isotopes - chemistry
Case-Control Studies
Child
Child, Preschool
Disease Progression
Female
Humans
Infant
Infant, Newborn
Kidney Cortex - chemistry
Kidney Cortex - pathology
Kidney Neoplasms - diagnosis
Male
Neoplasm Grading
Neoplasm Staging
Nitrogen Isotopes - chemistry
Prognosis
Research Paper
Wilms Tumor - diagnosis
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Summary:The paper describes a novel approach to investigating Wilms' tumour (nephroblastoma) biology at the atomic level. Isotope Ratio Mass Spectrometry (IRMS) was used to directly assess the isotope ratios of nitrogen and carbon in 84 Wilms' tumour tissue samples from 28 cases representing the histological spectrum of nephroblastoma. Marked differences in nitrogen and carbon isotope ratios were found between nephroblastoma histological types and along the course of cancer disease, with a breakout in isotope ratio of the examined elements in tumour tissue found between stages 2 and 3. Different isotopic compositions with regard to nitrogen and carbon content were observed in blastemal Wilms' tumour, with and without focal anaplasia, and in poorly- and well-differentiated epithelial nephroblastoma. This first assessment of nitrogen and carbon isotope ratio reveals the previously unknown part of Wilms' tumour biology and represents a potential novel biomarker, allowing for a highly individual approach to treating cancer. Furthermore, this method of estimating isotopic composition appears to be the most sensitive tool yet for cancer tissue evaluation, and a valuable complement to established cancer study methods with prospective clinical impact.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.12521