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Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families
Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development. To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen...
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| Published in: | American journal of respiratory and critical care medicine 2017-03, Vol.195 (5), p.674-681 |
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| cites | cdi_FETCH-LOGICAL-c451t-72be08185681a0c1f3ca1a58261806a0c1e6a4d8d00da897502331d9db5dce6b3 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | Ramratnam, Sima K Visness, Cynthia M Jaffee, Katy F Bloomberg, Gordon R Kattan, Meyer Sandel, Megan T Wood, Robert A Gern, James E Wright, Rosalind J |
| description | Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development.
To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years.
URECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years.
Overall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P |
| doi_str_mv | 10.1164/rccm.201602-0272OC |
| format | article |
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To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years.
URECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years.
Overall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P < 0.05). Maternal depression (any year) was significantly associated with recurrent wheezing (P ≤ 0.01). These associations were also significant when considered in a longitudinal analysis of cumulative stress and depression (P ≤ 0.02). Neither stress nor depression was significantly related to aeroallergen sensitization or antiviral responses. Contrary to our original hypothesis, prenatal and Year 1 stress and depression had significant inverse associations with several type 2 cytokine responses.
In urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing but not increased atopy or reduced antiviral responses.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.201602-0272OC</identifier><identifier>PMID: 27654103</identifier><language>eng</language><publisher>United States: American Thoracic Society</publisher><subject>Asthma - epidemiology ; Asthma - immunology ; Asthma - psychology ; Child, Preschool ; Cytokines - immunology ; Depressive Disorder - epidemiology ; Depressive Disorder - immunology ; Depressive Disorder - psychology ; Female ; Humans ; Leukocytes, Mononuclear - immunology ; Male ; Mothers - psychology ; Original ; Poverty - psychology ; Pregnancy ; Pregnancy Complications - epidemiology ; Pregnancy Complications - immunology ; Pregnancy Complications - psychology ; Recurrence ; Respiratory Sounds - immunology ; Risk Factors ; Stress, Psychological - epidemiology ; Stress, Psychological - immunology ; Stress, Psychological - psychology ; Urban Population - statistics & numerical data</subject><ispartof>American journal of respiratory and critical care medicine, 2017-03, Vol.195 (5), p.674-681</ispartof><rights>Copyright © 2017 by the American Thoracic Society 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-72be08185681a0c1f3ca1a58261806a0c1e6a4d8d00da897502331d9db5dce6b3</citedby><cites>FETCH-LOGICAL-c451t-72be08185681a0c1f3ca1a58261806a0c1e6a4d8d00da897502331d9db5dce6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27654103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramratnam, Sima K</creatorcontrib><creatorcontrib>Visness, Cynthia M</creatorcontrib><creatorcontrib>Jaffee, Katy F</creatorcontrib><creatorcontrib>Bloomberg, Gordon R</creatorcontrib><creatorcontrib>Kattan, Meyer</creatorcontrib><creatorcontrib>Sandel, Megan T</creatorcontrib><creatorcontrib>Wood, Robert A</creatorcontrib><creatorcontrib>Gern, James E</creatorcontrib><creatorcontrib>Wright, Rosalind J</creatorcontrib><title>Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development.
To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years.
URECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years.
Overall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P < 0.05). Maternal depression (any year) was significantly associated with recurrent wheezing (P ≤ 0.01). These associations were also significant when considered in a longitudinal analysis of cumulative stress and depression (P ≤ 0.02). Neither stress nor depression was significantly related to aeroallergen sensitization or antiviral responses. Contrary to our original hypothesis, prenatal and Year 1 stress and depression had significant inverse associations with several type 2 cytokine responses.
In urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing but not increased atopy or reduced antiviral responses.</description><subject>Asthma - epidemiology</subject><subject>Asthma - immunology</subject><subject>Asthma - psychology</subject><subject>Child, Preschool</subject><subject>Cytokines - immunology</subject><subject>Depressive Disorder - epidemiology</subject><subject>Depressive Disorder - immunology</subject><subject>Depressive Disorder - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Male</subject><subject>Mothers - psychology</subject><subject>Original</subject><subject>Poverty - psychology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Complications - immunology</subject><subject>Pregnancy Complications - psychology</subject><subject>Recurrence</subject><subject>Respiratory Sounds - immunology</subject><subject>Risk Factors</subject><subject>Stress, Psychological - epidemiology</subject><subject>Stress, Psychological - immunology</subject><subject>Stress, Psychological - psychology</subject><subject>Urban Population - statistics & numerical data</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkc1u1DAUhSMEoqXwAiyQlyya4v84G6RqoFBpUKWhFbCybpw7M0aJHewMqDwBj42HKRWs7tW55xxb-qrqOaNnjGn5Kjk3nnHKNOU15Q2_WjyojpkSqpZtQx-WnTailrL9fFQ9yfkrpYwbRh9XR7zRSjIqjqtfKxxg9jHkrZ8ygTGGDfkAM6YAA_k4J8xFDT15g9N-L85Tcn07IeFkhXkqQcynfxwrdLuUMMzk0xbxpy9FMJPzDRJBviCkTHwgy_ijvgwujkhuUgeBXMDoB4_5afVoDUPGZ3fzpLq5eHu9eF8vr95dLs6XtZOKzXXDO6SGGaUNA-rYWjhgoAzXzFC9V1CD7E1PaQ-mbRTlQrC-7TvVO9SdOKleH3qnXTdi0cKcYLBT8iOkWxvB2_8vwW_tJn63SmjRNrIUvLwrSPHbDvNsR58dDgMEjLtsmRFKClO4FCs_WF2KOSdc3z_DqN0jtHuE9oDQHhCW0It_P3gf-ctM_AYk1JoG</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Ramratnam, Sima K</creator><creator>Visness, Cynthia M</creator><creator>Jaffee, Katy F</creator><creator>Bloomberg, Gordon R</creator><creator>Kattan, Meyer</creator><creator>Sandel, Megan T</creator><creator>Wood, Robert A</creator><creator>Gern, James E</creator><creator>Wright, Rosalind J</creator><general>American Thoracic Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170301</creationdate><title>Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families</title><author>Ramratnam, Sima K ; Visness, Cynthia M ; Jaffee, Katy F ; Bloomberg, Gordon R ; Kattan, Meyer ; Sandel, Megan T ; Wood, Robert A ; Gern, James E ; Wright, Rosalind J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-72be08185681a0c1f3ca1a58261806a0c1e6a4d8d00da897502331d9db5dce6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Asthma - epidemiology</topic><topic>Asthma - immunology</topic><topic>Asthma - psychology</topic><topic>Child, Preschool</topic><topic>Cytokines - immunology</topic><topic>Depressive Disorder - epidemiology</topic><topic>Depressive Disorder - immunology</topic><topic>Depressive Disorder - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Male</topic><topic>Mothers - psychology</topic><topic>Original</topic><topic>Poverty - psychology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Pregnancy Complications - immunology</topic><topic>Pregnancy Complications - psychology</topic><topic>Recurrence</topic><topic>Respiratory Sounds - immunology</topic><topic>Risk Factors</topic><topic>Stress, Psychological - epidemiology</topic><topic>Stress, Psychological - immunology</topic><topic>Stress, Psychological - psychology</topic><topic>Urban Population - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramratnam, Sima K</creatorcontrib><creatorcontrib>Visness, Cynthia M</creatorcontrib><creatorcontrib>Jaffee, Katy F</creatorcontrib><creatorcontrib>Bloomberg, Gordon R</creatorcontrib><creatorcontrib>Kattan, Meyer</creatorcontrib><creatorcontrib>Sandel, Megan T</creatorcontrib><creatorcontrib>Wood, Robert A</creatorcontrib><creatorcontrib>Gern, James E</creatorcontrib><creatorcontrib>Wright, Rosalind J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramratnam, Sima K</au><au>Visness, Cynthia M</au><au>Jaffee, Katy F</au><au>Bloomberg, Gordon R</au><au>Kattan, Meyer</au><au>Sandel, Megan T</au><au>Wood, Robert A</au><au>Gern, James E</au><au>Wright, Rosalind J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>195</volume><issue>5</issue><spage>674</spage><epage>681</epage><pages>674-681</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Maternal depression and prenatal and early life stress may influence childhood wheezing illnesses, potentially through effects on immune development.
To test the hypothesis that maternal stress and/or depression during pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and altered cytokine responses (enhanced type 2 or reduced virus-induced cytokine responses) from stimulated peripheral blood mononuclear cells at age 3 years.
URECA (Urban Environment and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities. Maternal stress, depression, and childhood wheezing episodes were assessed by quarterly questionnaires beginning at birth. Logistic and linear regression techniques were used to examine the relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell cytokine responses at age 3 years.
Overall, 166 (36%) children had recurrent wheeze at age 3 years. Measures of maternal perceived stress at Years 2 and 3 were positively associated with recurrent wheeze (P < 0.05). Maternal depression (any year) was significantly associated with recurrent wheezing (P ≤ 0.01). These associations were also significant when considered in a longitudinal analysis of cumulative stress and depression (P ≤ 0.02). Neither stress nor depression was significantly related to aeroallergen sensitization or antiviral responses. Contrary to our original hypothesis, prenatal and Year 1 stress and depression had significant inverse associations with several type 2 cytokine responses.
In urban children at high risk for asthma, maternal perceived stress and depression were significantly associated with recurrent wheezing but not increased atopy or reduced antiviral responses.</abstract><cop>United States</cop><pub>American Thoracic Society</pub><pmid>27654103</pmid><doi>10.1164/rccm.201602-0272OC</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Freely Accessible Science Journals - check A-Z of ejournals; EZB Electronic Journals Library |
| subjects | Asthma - epidemiology Asthma - immunology Asthma - psychology Child, Preschool Cytokines - immunology Depressive Disorder - epidemiology Depressive Disorder - immunology Depressive Disorder - psychology Female Humans Leukocytes, Mononuclear - immunology Male Mothers - psychology Original Poverty - psychology Pregnancy Pregnancy Complications - epidemiology Pregnancy Complications - immunology Pregnancy Complications - psychology Recurrence Respiratory Sounds - immunology Risk Factors Stress, Psychological - epidemiology Stress, Psychological - immunology Stress, Psychological - psychology Urban Population - statistics & numerical data |
| title | Relationships among Maternal Stress and Depression, Type 2 Responses, and Recurrent Wheezing at Age 3 Years in Low-Income Urban Families |
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