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Accuracy of left ventricular ejection fraction by contemporary multiple gated acquisition scanning in patients with cancer: comparison with cardiovascular magnetic resonance

Multiple gated acquisition scanning (MUGA) is a common imaging modality for baseline and serial assessment of left ventricular ejection fraction (LVEF) for cardiotoxicity risk assessment prior to, surveillance during, and surveillance after administration of potentially cardiotoxic cancer treatment....

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Published in:Journal of cardiovascular magnetic resonance 2017-03, Vol.19 (1), p.34, Article 34
Main Authors: Huang, Hans, Nijjar, Prabhjot S, Misialek, Jeffrey R, Blaes, Anne, Derrico, Nicholas P, Kazmirczak, Felipe, Klem, Igor, Farzaneh-Far, Afshin, Shenoy, Chetan
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cited_by cdi_FETCH-LOGICAL-c427t-57cfe74131fad3d26ddadfbe493613b5ea1cc67fbffca9e7c7b086261396c9453
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container_title Journal of cardiovascular magnetic resonance
container_volume 19
creator Huang, Hans
Nijjar, Prabhjot S
Misialek, Jeffrey R
Blaes, Anne
Derrico, Nicholas P
Kazmirczak, Felipe
Klem, Igor
Farzaneh-Far, Afshin
Shenoy, Chetan
description Multiple gated acquisition scanning (MUGA) is a common imaging modality for baseline and serial assessment of left ventricular ejection fraction (LVEF) for cardiotoxicity risk assessment prior to, surveillance during, and surveillance after administration of potentially cardiotoxic cancer treatment. The objective of this study was to compare the accuracy of left ventricular ejection fractions (LVEF) obtained by contemporary clinical multiple gated acquisition scans (MUGA) with reference LVEFs from cardiovascular magnetic resonance (CMR) in consecutive patients with cancer. In a cross-sectional study, we compared MUGA clinical and CMR reference LVEFs in 75 patients with cancer who had both studies within 30 days. Misclassification was assessed using the two most common thresholds of LVEF used in cardiotoxicity clinical studies and practice: 50 and 55%. Compared to CMR reference LVEFs, MUGA clinical LVEFs were only lower by a mean of 1.5% (48.5% vs. 50.0%, p = 0.17). However, the limits of agreement between MUGA clinical and CMR reference LVEFs were wide at -19.4 to 16.5%. At LVEF thresholds of 50 and 55%, there was misclassification of 35 and 20% of cancer patients, respectively. MUGA clinical LVEFs are only modestly accurate when compared with CMR reference LVEFs. These data have significant implications on clinical research and patient care of a population with, or at risk for, cardiotoxicity.
doi_str_mv 10.1186/s12968-017-0348-4
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The objective of this study was to compare the accuracy of left ventricular ejection fractions (LVEF) obtained by contemporary clinical multiple gated acquisition scans (MUGA) with reference LVEFs from cardiovascular magnetic resonance (CMR) in consecutive patients with cancer. In a cross-sectional study, we compared MUGA clinical and CMR reference LVEFs in 75 patients with cancer who had both studies within 30 days. Misclassification was assessed using the two most common thresholds of LVEF used in cardiotoxicity clinical studies and practice: 50 and 55%. Compared to CMR reference LVEFs, MUGA clinical LVEFs were only lower by a mean of 1.5% (48.5% vs. 50.0%, p = 0.17). However, the limits of agreement between MUGA clinical and CMR reference LVEFs were wide at -19.4 to 16.5%. At LVEF thresholds of 50 and 55%, there was misclassification of 35 and 20% of cancer patients, respectively. MUGA clinical LVEFs are only modestly accurate when compared with CMR reference LVEFs. These data have significant implications on clinical research and patient care of a population with, or at risk for, cardiotoxicity.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>28335788</pmid><doi>10.1186/s12968-017-0348-4</doi><oa>free_for_read</oa></addata></record>
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subjects Aged
Antineoplastic Agents - adverse effects
Breast cancer
Cancer
Cancer therapies
Cardiac-Gated Imaging Techniques
Cardiotoxicity
Colleges & universities
Cross-Sectional Studies
Family medical history
Female
Heart
Heart Diseases - chemically induced
Heart Diseases - diagnostic imaging
Heart Diseases - physiopathology
Heart failure
Humans
Image Interpretation, Computer-Assisted - methods
Magnetic resonance
Magnetic Resonance Imaging, Cine - methods
Male
Middle Aged
Neoplasms - drug therapy
NMR
Nuclear magnetic resonance
Patients
Predictive Value of Tests
Radionuclide Imaging - methods
Reproducibility of Results
Resonance
Risk assessment
Scanning
Stroke Volume - drug effects
Surveillance
Thresholds
Time Factors
Ventricle
Ventricular Function, Left - drug effects
title Accuracy of left ventricular ejection fraction by contemporary multiple gated acquisition scanning in patients with cancer: comparison with cardiovascular magnetic resonance
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