Association of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders with Mean Platelet Volume and Vitamin D

BACKGROUND The purpose of this study was to assess the values of the mean platelet volume (MPV) in children with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASDs) to determine the risk of cardiovascular disease in these 2 disorder groups. MATERIAL AND METHODS...

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Bibliographic Details
Published in:Medical science monitor 2017-03, Vol.23, p.1378-1384
Main Authors: Garipardic, Mesut, Doğan, Murat, Bala, Keziban Asli, Mutluer, Tuba, Kaba, Sultan, Aslan, Oktay, Üstyol, Lokman
Format: Article
Language:English
Subjects:
Adolescent
Attention Deficit Disorder with Hyperactivity - blood
Attention Deficit Disorder with Hyperactivity - complications
Attention Deficit Disorder with Hyperactivity - metabolism
Autism Spectrum Disorder - blood
Autism Spectrum Disorder - complications
Autism Spectrum Disorder - metabolism
Avitaminosis - complications
Biomarkers - blood
Cardiovascular Diseases - etiology
Child
Clinical Research
Female
Humans
Male
Mean Platelet Volume
Risk Factors
Vitamin B 12 - analysis
Vitamin B 12 - blood
Vitamin D - analysis
Vitamin D - blood
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Summary:BACKGROUND The purpose of this study was to assess the values of the mean platelet volume (MPV) in children with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASDs) to determine the risk of cardiovascular disease in these 2 disorder groups. MATERIAL AND METHODS The study included a total of 79 patients with ADHD or ASDs and controls in the Van region of Turkey. The control group included subjects of matching age and sex with no ADHD, ASDs, or chronic disease and taking no vitamins. The hematological parameters of the patients, including MPV, vitamin B12, and vitamin D, were assessed. RESULTS The study included a total of 79 children and adolescents aged 2-18 years (32 females and 47 males). Of the patients, 36 were in the ADHD group, 18 in the ASDs group, and 25 in the control group. There was no statistically significant difference in hematological parameters between the groups, but there were significant differences in terms of vitamin D and vitamin B12. The patient groups showed lower levels of vitamin B12 and vitamin D. In the ADHD group, there was a negative correlation between both vitamins and MPV (p
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.899976