Molecular Mechanism of Rheumatic Diseases and Efficacy of Current Therapies

[...]the interest in alternative, well tolerated anti-inflammatory remedies has reemerged. P. Klinger et al. investigate the role of pigment epithelium-derived factor PEDF on the genome-wide gene expression, a pluripotent protein expressed in multiple tissues and involved in multiple signaling pathw...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017, p.2401329-2
Main Authors: Umar, Sadiq, Tyagi, Abdul M., Singh, Anil K., Haseeb, Abdul
Format: Article
Language:English
Subjects:
Animals
Chronic illnesses
Cytokines
Fibromyalgia
Gene expression
Humans
Lupus
Quality of life
Rheumatic diseases
Rheumatic Diseases - genetics
Rheumatic Diseases - immunology
Rheumatic Diseases - metabolism
Rheumatic Diseases - therapy
Rheumatoid arthritis
Studies
TNF inhibitors
Tumor necrosis factor-TNF
Citations: Items that cite this one
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Summary:[...]the interest in alternative, well tolerated anti-inflammatory remedies has reemerged. P. Klinger et al. investigate the role of pigment epithelium-derived factor PEDF on the genome-wide gene expression, a pluripotent protein expressed in multiple tissues and involved in multiple signaling pathways, including the IP3-AKT, MEK-ERK, or PLA2-PPAR pathway, and showed it as marker and future therapy to stabilize the chondrocyte phenotype of articular cartilage and to prevent its degradation.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/2401329