Head-to-head comparison of 11C-PiB and 18F-FC119S for Aβ imaging in healthy subjects, mild cognitive impairment patients, and Alzheimer's disease patients

• Published in: Medicine (Baltimore) 2017-03, Vol.96 (12), p.e6441-e6441
• Main Authors: Byun, Byung Hyun, Kim, Byung Il, Park, Su Yeon, Ko, In Ok, Lee, Kyo Chul, Kim, Kyeong Min, Kim, Yu Kyeong, Lee, Jun-Young, Bu, Seon Hee, Kim, Jung Hwa, Chi, Dae Yoon, Ha, Jeong Ho, Lim, Sang Moo
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Aniline Compounds; Benzothiazoles; Brain - diagnostic imaging; Brain - pathology; Carbon Radioisotopes; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - pathology; Female; Fluorine Radioisotopes; Healthy Volunteers; Humans; Male; Middle Aged; Observational Study; Positron-Emission Tomography - methods; Thiazoles
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000006441

As a new beta amyloid (Aβ) positron emission tomography (PET) tracer, F-FC119S has shown higher cortical uptake in patients with Alzheimer's disease (AD) than that in healthy control subjects without adverse effects in a previous preliminary study. The aim of this study was to compare F-FC119S PET and C-PiB PET in healthy control (HC) subjects, mild cognitive impairment (MCI) patients, and AD patients.A total of 48 subjects, including 28 HC subjects, 10 MCI patients, and 10 AD patients, underwent static F-FC119S PET (30 minutes after intravenous [i.v.] injection) and C-PiB PET (40 minutes after i.v. injection) on the same day. Both PET images were visually and quantitatively assessed. Standardized uptake value ratios (SUVRs) were calculated for each brain region using the cerebellar cortex as a reference region.None (0%) of the 28 HC subjects and 4 (40%) of 10 MCI patients had positive scans on both PET images. Of the 10 AD patients, 7 (70%) had positive scans on C-PiB PET while 6 (60%) had positive scans on F-FC119S PET. Overall, 47 (98%) of 48 participants showed identical results based on visual analysis. Cortical SUVR of F-FC119S was higher in AD patients (1.38 ± 0.16), followed by that in MCI patients (1.24 ± 0.10) and in HC subjects (1.14 ± 0.05). Compared with C-PiB PET, F-FC119S PET yielded a higher effect size (d = 2.02 vs. 1.67) in AD patients and a slightly lower effect size (d = 1.26 vs. 1.38) in MCI patients. In HC subjects, the nonspecific binding of F-FC119S to white matter (with the frontal cortex-to-white matter SUV ratio of 0.76) was slightly lower than that of C-PiB (ratio of 0.73). There was a significant linear correlation (slope = 0.41, r = 0.78, P