Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi

Subtilases belong to a superfamily of serine proteases which are ubiquitous in fungi and are suspected to have developed distinct functional properties to help fungi adapt to different ecological niches. In this study, we conducted a large-scale phylogenomic survey of subtilase protease genes in 83...

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Bibliographic Details
Published in:Scientific reports 2017-03, Vol.7 (1), p.45456-45456, Article 45456
Main Authors: Li, Juan, Gu, Fei, Wu, Runian, Yang, JinKui, Zhang, Ke-Qin
Format: Article
Language:English
Subjects:
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Divergence
Endopeptidase K
Enzymes
Evolution
Evolution, Molecular
Fungal Proteins - classification
Fungal Proteins - genetics
Fungi
Fungi - enzymology
Fungi - genetics
Gene Duplication
Genome, Fungal
Genomes
Genomic analysis
Humanities and Social Sciences
Kexin
multidisciplinary
Niches
Phylogeny
Proteinase
Science
Serine
Subtilase
Subtilisins - classification
Subtilisins - genetics
Whole Genome Sequencing
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Summary:Subtilases belong to a superfamily of serine proteases which are ubiquitous in fungi and are suspected to have developed distinct functional properties to help fungi adapt to different ecological niches. In this study, we conducted a large-scale phylogenomic survey of subtilase protease genes in 83 whole genome sequenced fungal species in order to identify the evolutionary patterns and subsequent functional divergences of different subtilase families among the main lineages of the fungal kingdom. Our comparative genomic analyses of the subtilase superfamily indicated that extensive gene duplications, losses and functional diversifications have occurred in fungi, and that the four families of subtilase enzymes in fungi, including proteinase K-like, Pyrolisin, kexin and S53, have distinct evolutionary histories which may have facilitated the adaptation of fungi to a broad array of life strategies. Our study provides new insights into the evolution of the subtilase superfamily in fungi and expands our understanding of the evolution of fungi with different lifestyles.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep45456