Management of Hepple Stage V Osteochondral Lesion of the Talus with a Platelet-Rich Plasma Scaffold

There has been no consensus on the treatment or prognosis of Hepple stage V osteochondral lesions of the talus (OLTs), especially for lesions greater than 1.5 cm2 in size. The objective of this study was to investigate the clinical outcomes achieved upon application of a platelet-rich plasma (PRP) s...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-6
Main Authors: Xu, Hongwei, Zhang, Haotong, Zou, Jian, Xue, Jianfeng, Mei, Guohua, Shi, Zhongmin, Li, Tanzhu, Gu, Wenqi, Wang, Xiaokang
Format: Article
Language:English
Subjects:
Adult
Ankle
Arthroscopy - methods
Biomedical research
Bone Regeneration
Bone Transplantation
Cartilage, Articular - growth & development
Cartilage, Articular - pathology
Clinical outcomes
Clinical Study
Cysts
Female
Hospitals
Humans
Injuries
Knee
Magnetic Resonance Imaging
Male
Middle Aged
Osteochondrosis - diagnostic imaging
Osteochondrosis - drug therapy
Osteochondrosis - physiopathology
Osteochondrosis - surgery
Patients
Plasma
Platelet-Rich Plasma
Prognosis
Skin & tissue grafts
Surgeons
Talus - diagnostic imaging
Talus - drug effects
Talus - physiopathology
Talus - surgery
Tissue Scaffolds
Treatment Outcome
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Summary:There has been no consensus on the treatment or prognosis of Hepple stage V osteochondral lesions of the talus (OLTs), especially for lesions greater than 1.5 cm2 in size. The objective of this study was to investigate the clinical outcomes achieved upon application of a platelet-rich plasma (PRP) scaffold with a cancellous bone autograft for Hepple stage V OLTs. Fourteen patients (mean age, 39 years) were treated with a cancellous bone graft and a PRP scaffold between 2013 and 2015. The mean time to surgical treatment was 23.5 months. Ankle X-ray and magnetic resonance imaging were performed at the final follow-up. Functional outcomes were evaluated according to the Visual Analog Scale (VAS) score, American Orthopaedic Foot and Ankle Society (AOFAS) score, and Short Form 36 (SF-36) score. The range of motion (ROM) of the ankle joint and complications also were recorded. Thirteen patients completed the full follow-up, with a mean follow-up duration of 18 months. MRI demonstrated the complete regeneration of subchondral bone and cartilage in all patients. The postoperative VAS, AOFAS ankle and hindfoot, and SF-36 scores were improved significantly (all P
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/6525373