Loading…

Transcranial low level laser (light) therapy for traumatic brain injury

We review the use of transcranial low‐level laser (light) therapy (LLLT) as a possible treatment for traumatic‐brain injury (TBI). The basic mechanisms of LLLT at the cellular and molecular level and its effects on the brain are outlined. Many interacting processes may contribute to the beneficial e...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biophotonics 2012-11, Vol.5 (11-12), p.827-837
Main Authors: Huang, Ying-Ying, Gupta, Asheesh, Vecchio, Daniela, Arce, Vida J. Bil de, Huang, Shih-Fong, Xuan, Weijun, Hamblin, Michael R.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5727-d2199a2f0f954d1d3838a99754977fce73109fd00a1ab5340a731d0523310e8f3
cites cdi_FETCH-LOGICAL-c5727-d2199a2f0f954d1d3838a99754977fce73109fd00a1ab5340a731d0523310e8f3
container_end_page 837
container_issue 11-12
container_start_page 827
container_title Journal of biophotonics
container_volume 5
creator Huang, Ying-Ying
Gupta, Asheesh
Vecchio, Daniela
Arce, Vida J. Bil de
Huang, Shih-Fong
Xuan, Weijun
Hamblin, Michael R.
description We review the use of transcranial low‐level laser (light) therapy (LLLT) as a possible treatment for traumatic‐brain injury (TBI). The basic mechanisms of LLLT at the cellular and molecular level and its effects on the brain are outlined. Many interacting processes may contribute to the beneficial effects in TBI including neuroprotection, reduction of inflammation and stimulation of neurogenesis. Animal studies and clinical trials of transcranial‐LLLT for ischemic stroke are summarized. Several laboratories have shown that LLLT is effective in increasing neurological performance and memory and learning in mouse models of TBI. There have been case report papers that show beneficial effects of transcranial‐LLLT in a total of three patients with chronic TBI. Our laboratory has conducted three studies on LLLT and TBI in mice. One looked at pulsed‐vs‐continuous wave laser‐irradiation and found 10 Hz to be superior. The second looked at four different laser‐wavelengths (660, 730, 810, and 980 nm); only 660 and 810 nm were effective. The last looked at different treatment repetition regimens (1, 3 and 14‐daily laser‐treatments). (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
doi_str_mv 10.1002/jbio.201200077
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5379852</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2808778711</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5727-d2199a2f0f954d1d3838a99754977fce73109fd00a1ab5340a731d0523310e8f3</originalsourceid><addsrcrecordid>eNqFkU1vEzEQhi1ERUvgyhGtxKUcNoy_1vYFiVY0LYropajcLGfX2zg469TebZt_X0dpV4ULF9vyPPNoRi9CHzBMMQD5slq4MCWACQAI8QodYVmxEiomX49v-vsQvU1pBVAB5fQNOiREgmCEHKHZVTRdqvPhjC98uC-8vbP5ZZKNxbF3N8v-c9EvbTSbbdGGWPTRDGvTu7pYROO6wnWrIW7foYPW-GTfP90T9Ovs-9XpeTm_nF2cfpuXNRdElA3BShnSQqs4a3BDJZVGKcGZEqKtraAYVNsAGGwWnDIw-acBTmguWNnSCfq6926Gxdo2te3yPF5volubuNXBOP13pXNLfRPuNKdCyeyZoOMnQQy3g029XrtUW-9NZ8OQNMaMSsU5sIx--gddhSF2eb1M0bwAZWInnO6pOoaUom3HYTDoXUZ6l5EeM8oNH1-uMOLPoWRA7YF75-32Pzr94-Ti8qW83Pe61NuHsdfEP7oSVHB9_XOmCZXzkyr7rukjQLOr8g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1139543472</pqid></control><display><type>article</type><title>Transcranial low level laser (light) therapy for traumatic brain injury</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Huang, Ying-Ying ; Gupta, Asheesh ; Vecchio, Daniela ; Arce, Vida J. Bil de ; Huang, Shih-Fong ; Xuan, Weijun ; Hamblin, Michael R.</creator><creatorcontrib>Huang, Ying-Ying ; Gupta, Asheesh ; Vecchio, Daniela ; Arce, Vida J. Bil de ; Huang, Shih-Fong ; Xuan, Weijun ; Hamblin, Michael R.</creatorcontrib><description>We review the use of transcranial low‐level laser (light) therapy (LLLT) as a possible treatment for traumatic‐brain injury (TBI). The basic mechanisms of LLLT at the cellular and molecular level and its effects on the brain are outlined. Many interacting processes may contribute to the beneficial effects in TBI including neuroprotection, reduction of inflammation and stimulation of neurogenesis. Animal studies and clinical trials of transcranial‐LLLT for ischemic stroke are summarized. Several laboratories have shown that LLLT is effective in increasing neurological performance and memory and learning in mouse models of TBI. There have been case report papers that show beneficial effects of transcranial‐LLLT in a total of three patients with chronic TBI. Our laboratory has conducted three studies on LLLT and TBI in mice. One looked at pulsed‐vs‐continuous wave laser‐irradiation and found 10 Hz to be superior. The second looked at four different laser‐wavelengths (660, 730, 810, and 980 nm); only 660 and 810 nm were effective. The last looked at different treatment repetition regimens (1, 3 and 14‐daily laser‐treatments). (© 2012 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)</description><identifier>ISSN: 1864-063X</identifier><identifier>EISSN: 1864-0648</identifier><identifier>DOI: 10.1002/jbio.201200077</identifier><identifier>PMID: 22807422</identifier><language>eng</language><publisher>Berlin: WILEY-VCH Verlag</publisher><subject>Animals ; Brain Injuries - radiotherapy ; clinical trials ; Humans ; Low level laser therapy ; Low-Level Light Therapy - methods ; mouse models ; neurogenesis ; NIR laser ; photobiomodulation ; Skull ; stroke ; Stroke - radiotherapy ; traumatic brain injury</subject><ispartof>Journal of biophotonics, 2012-11, Vol.5 (11-12), p.827-837</ispartof><rights>Copyright © 2012 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><rights>Copyright © 2012 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.</rights><rights>Copyright © 2012 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5727-d2199a2f0f954d1d3838a99754977fce73109fd00a1ab5340a731d0523310e8f3</citedby><cites>FETCH-LOGICAL-c5727-d2199a2f0f954d1d3838a99754977fce73109fd00a1ab5340a731d0523310e8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22807422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Ying-Ying</creatorcontrib><creatorcontrib>Gupta, Asheesh</creatorcontrib><creatorcontrib>Vecchio, Daniela</creatorcontrib><creatorcontrib>Arce, Vida J. Bil de</creatorcontrib><creatorcontrib>Huang, Shih-Fong</creatorcontrib><creatorcontrib>Xuan, Weijun</creatorcontrib><creatorcontrib>Hamblin, Michael R.</creatorcontrib><title>Transcranial low level laser (light) therapy for traumatic brain injury</title><title>Journal of biophotonics</title><addtitle>J. Biophoton</addtitle><description>We review the use of transcranial low‐level laser (light) therapy (LLLT) as a possible treatment for traumatic‐brain injury (TBI). The basic mechanisms of LLLT at the cellular and molecular level and its effects on the brain are outlined. Many interacting processes may contribute to the beneficial effects in TBI including neuroprotection, reduction of inflammation and stimulation of neurogenesis. Animal studies and clinical trials of transcranial‐LLLT for ischemic stroke are summarized. Several laboratories have shown that LLLT is effective in increasing neurological performance and memory and learning in mouse models of TBI. There have been case report papers that show beneficial effects of transcranial‐LLLT in a total of three patients with chronic TBI. Our laboratory has conducted three studies on LLLT and TBI in mice. One looked at pulsed‐vs‐continuous wave laser‐irradiation and found 10 Hz to be superior. The second looked at four different laser‐wavelengths (660, 730, 810, and 980 nm); only 660 and 810 nm were effective. The last looked at different treatment repetition regimens (1, 3 and 14‐daily laser‐treatments). (© 2012 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)</description><subject>Animals</subject><subject>Brain Injuries - radiotherapy</subject><subject>clinical trials</subject><subject>Humans</subject><subject>Low level laser therapy</subject><subject>Low-Level Light Therapy - methods</subject><subject>mouse models</subject><subject>neurogenesis</subject><subject>NIR laser</subject><subject>photobiomodulation</subject><subject>Skull</subject><subject>stroke</subject><subject>Stroke - radiotherapy</subject><subject>traumatic brain injury</subject><issn>1864-063X</issn><issn>1864-0648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkU1vEzEQhi1ERUvgyhGtxKUcNoy_1vYFiVY0LYropajcLGfX2zg469TebZt_X0dpV4ULF9vyPPNoRi9CHzBMMQD5slq4MCWACQAI8QodYVmxEiomX49v-vsQvU1pBVAB5fQNOiREgmCEHKHZVTRdqvPhjC98uC-8vbP5ZZKNxbF3N8v-c9EvbTSbbdGGWPTRDGvTu7pYROO6wnWrIW7foYPW-GTfP90T9Ovs-9XpeTm_nF2cfpuXNRdElA3BShnSQqs4a3BDJZVGKcGZEqKtraAYVNsAGGwWnDIw-acBTmguWNnSCfq6926Gxdo2te3yPF5volubuNXBOP13pXNLfRPuNKdCyeyZoOMnQQy3g029XrtUW-9NZ8OQNMaMSsU5sIx--gddhSF2eb1M0bwAZWInnO6pOoaUom3HYTDoXUZ6l5EeM8oNH1-uMOLPoWRA7YF75-32Pzr94-Ti8qW83Pe61NuHsdfEP7oSVHB9_XOmCZXzkyr7rukjQLOr8g</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Huang, Ying-Ying</creator><creator>Gupta, Asheesh</creator><creator>Vecchio, Daniela</creator><creator>Arce, Vida J. Bil de</creator><creator>Huang, Shih-Fong</creator><creator>Xuan, Weijun</creator><creator>Hamblin, Michael R.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>K9.</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201211</creationdate><title>Transcranial low level laser (light) therapy for traumatic brain injury</title><author>Huang, Ying-Ying ; Gupta, Asheesh ; Vecchio, Daniela ; Arce, Vida J. Bil de ; Huang, Shih-Fong ; Xuan, Weijun ; Hamblin, Michael R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5727-d2199a2f0f954d1d3838a99754977fce73109fd00a1ab5340a731d0523310e8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Brain Injuries - radiotherapy</topic><topic>clinical trials</topic><topic>Humans</topic><topic>Low level laser therapy</topic><topic>Low-Level Light Therapy - methods</topic><topic>mouse models</topic><topic>neurogenesis</topic><topic>NIR laser</topic><topic>photobiomodulation</topic><topic>Skull</topic><topic>stroke</topic><topic>Stroke - radiotherapy</topic><topic>traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Ying-Ying</creatorcontrib><creatorcontrib>Gupta, Asheesh</creatorcontrib><creatorcontrib>Vecchio, Daniela</creatorcontrib><creatorcontrib>Arce, Vida J. Bil de</creatorcontrib><creatorcontrib>Huang, Shih-Fong</creatorcontrib><creatorcontrib>Xuan, Weijun</creatorcontrib><creatorcontrib>Hamblin, Michael R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biophotonics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Ying-Ying</au><au>Gupta, Asheesh</au><au>Vecchio, Daniela</au><au>Arce, Vida J. Bil de</au><au>Huang, Shih-Fong</au><au>Xuan, Weijun</au><au>Hamblin, Michael R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcranial low level laser (light) therapy for traumatic brain injury</atitle><jtitle>Journal of biophotonics</jtitle><addtitle>J. Biophoton</addtitle><date>2012-11</date><risdate>2012</risdate><volume>5</volume><issue>11-12</issue><spage>827</spage><epage>837</epage><pages>827-837</pages><issn>1864-063X</issn><eissn>1864-0648</eissn><abstract>We review the use of transcranial low‐level laser (light) therapy (LLLT) as a possible treatment for traumatic‐brain injury (TBI). The basic mechanisms of LLLT at the cellular and molecular level and its effects on the brain are outlined. Many interacting processes may contribute to the beneficial effects in TBI including neuroprotection, reduction of inflammation and stimulation of neurogenesis. Animal studies and clinical trials of transcranial‐LLLT for ischemic stroke are summarized. Several laboratories have shown that LLLT is effective in increasing neurological performance and memory and learning in mouse models of TBI. There have been case report papers that show beneficial effects of transcranial‐LLLT in a total of three patients with chronic TBI. Our laboratory has conducted three studies on LLLT and TBI in mice. One looked at pulsed‐vs‐continuous wave laser‐irradiation and found 10 Hz to be superior. The second looked at four different laser‐wavelengths (660, 730, 810, and 980 nm); only 660 and 810 nm were effective. The last looked at different treatment repetition regimens (1, 3 and 14‐daily laser‐treatments). (© 2012 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)</abstract><cop>Berlin</cop><pub>WILEY-VCH Verlag</pub><pmid>22807422</pmid><doi>10.1002/jbio.201200077</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1864-063X
ispartof Journal of biophotonics, 2012-11, Vol.5 (11-12), p.827-837
issn 1864-063X
1864-0648
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5379852
source Wiley-Blackwell Read & Publish Collection
subjects Animals
Brain Injuries - radiotherapy
clinical trials
Humans
Low level laser therapy
Low-Level Light Therapy - methods
mouse models
neurogenesis
NIR laser
photobiomodulation
Skull
stroke
Stroke - radiotherapy
traumatic brain injury
title Transcranial low level laser (light) therapy for traumatic brain injury
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T21%3A17%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transcranial%20low%20level%20laser%20(light)%20therapy%20for%20traumatic%20brain%20injury&rft.jtitle=Journal%20of%20biophotonics&rft.au=Huang,%20Ying-Ying&rft.date=2012-11&rft.volume=5&rft.issue=11-12&rft.spage=827&rft.epage=837&rft.pages=827-837&rft.issn=1864-063X&rft.eissn=1864-0648&rft_id=info:doi/10.1002/jbio.201200077&rft_dat=%3Cproquest_pubme%3E2808778711%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5727-d2199a2f0f954d1d3838a99754977fce73109fd00a1ab5340a731d0523310e8f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1139543472&rft_id=info:pmid/22807422&rfr_iscdi=true