Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men

Highlights • Elevated cortisol does not appear to be associated with regional variations in hippocampal shape. • Novel shape morphology analysis applied to study possible effect of cortisol on hippocampus. • Mean diffusivity in hippocampus is associated with reactive cortisol slope in older men...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2017-04, Vol.78, p.151-158
Main Authors: Cox, Simon R, Hernández, Maria del Carmen Valdés, Kim, Jaeil, Royle, Natalie A, MacPherson, Sarah E, Ferguson, Karen J, Maniega, Susana Muñoz, Anblagan, Devasuda, Aribisala, Benjamin S, Bastin, Mark E, Park, Jinah, Starr, John M, Deary, Ian J, MacLullich, Alasdair M.J, Wardlaw, Joanna M
Format: Article
Language:English
Subjects:
3D shape analysis
Aged
Ageing
Brain
Cortisol
Endocrinology & Metabolism
Hippocampus
Hippocampus - diagnostic imaging
Humans
Hydrocortisone - analysis
Magnetic Resonance Imaging
Male
MRI
Organ Size - physiology
Psychiatry
Saliva - chemistry
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Summary:Highlights • Elevated cortisol does not appear to be associated with regional variations in hippocampal shape. • Novel shape morphology analysis applied to study possible effect of cortisol on hippocampus. • Mean diffusivity in hippocampus is associated with reactive cortisol slope in older men
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2017.01.027