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The Polydeoxyadenylate Tract of Alu Repetitive Elements is Polymorphic in the Human Genome
To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed th...
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| Published in: | Proceedings of the National Academy of Sciences - PNAS 1990-04, Vol.87 (8), p.2951-2954 |
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| Main Authors: | , , , |
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| container_end_page | 2954 |
| container_issue | 8 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 87 |
| creator | Economou, Effrosini P. Bergen, Andrew W. Warren, Andrew C. Antonarakis, Stylianos E. |
| description | To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3' ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the β-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome. |
| doi_str_mv | 10.1073/pnas.87.8.2951 |
| format | article |
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We analyzed the 3' ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the β-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.87.8.2951</identifier><identifier>PMID: 2326257</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>550201 - Biochemistry- Tracer Techniques ; 550401 - Genetics- Tracer Techniques ; Alleles ; ANIMALS ; Base Sequence ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL MARKERS ; Chromosome polymorphism ; Chromosomes ; Classical genetics, quantitative genetics, hybrids ; DAYS LIVING RADIOISOTOPES ; DNA ; DNA SEQUENCING ; ENZYMES ; Female ; Fundamental and applied biological sciences. 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Biological and molecular evolution ; Genome, Human ; GLOBINS ; Human ; Human genome ; Humans ; ISOTOPES ; LIGHT NUCLEI ; LYASES ; Male ; MAMMALS ; MAN ; Molecular Sequence Data ; NUCLEI ; Nucleotides ; ODD-ODD NUCLEI ; Oligonucleotide Probes ; Oligonucleotides ; ORGANIC COMPOUNDS ; Pedigree ; PHOSPHORUS 32 ; PHOSPHORUS ISOTOPES ; Poly A - genetics ; Polymerase chain reaction ; Polymorphism, Genetic ; PRIMATES ; PROTEINS ; RADIOISOTOPES ; Repetitive Sequences, Nucleic Acid ; RFLPS ; STRUCTURAL CHEMICAL ANALYSIS ; VERTEBRATES</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1990-04, Vol.87 (8), p.2951-2954</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-8e81547e7aac1d5126cbb24c375363a52b252dab0f4696e8d2a1a10f908d2e823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/87/8.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2354076$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2354076$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19407246$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2326257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6249545$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Economou, Effrosini P.</creatorcontrib><creatorcontrib>Bergen, Andrew W.</creatorcontrib><creatorcontrib>Warren, Andrew C.</creatorcontrib><creatorcontrib>Antonarakis, Stylianos E.</creatorcontrib><title>The Polydeoxyadenylate Tract of Alu Repetitive Elements is Polymorphic in the Human Genome</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3' ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the β-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.</description><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>550401 - Genetics- Tracer Techniques</subject><subject>Alleles</subject><subject>ANIMALS</subject><subject>Base Sequence</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MARKERS</subject><subject>Chromosome polymorphism</subject><subject>Chromosomes</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DNA</subject><subject>DNA SEQUENCING</subject><subject>ENZYMES</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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Biological and molecular evolution</subject><subject>Genome, Human</subject><subject>GLOBINS</subject><subject>Human</subject><subject>Human genome</subject><subject>Humans</subject><subject>ISOTOPES</subject><subject>LIGHT NUCLEI</subject><subject>LYASES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>Molecular Sequence Data</subject><subject>NUCLEI</subject><subject>Nucleotides</subject><subject>ODD-ODD NUCLEI</subject><subject>Oligonucleotide Probes</subject><subject>Oligonucleotides</subject><subject>ORGANIC COMPOUNDS</subject><subject>Pedigree</subject><subject>PHOSPHORUS 32</subject><subject>PHOSPHORUS ISOTOPES</subject><subject>Poly A - genetics</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Genetic</subject><subject>PRIMATES</subject><subject>PROTEINS</subject><subject>RADIOISOTOPES</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>RFLPS</subject><subject>STRUCTURAL CHEMICAL ANALYSIS</subject><subject>VERTEBRATES</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNqFkc1v1DAQxSMEKkvhygmkCIneEvwZOxKXqiotUiUQWi5cLMeZsK4cO8RO1f3v8bJLWS5wsqX3e29m9IriJUY1RoK-m7yOtRS1rEnL8aNihVGLq4a16HGxQoiISjLCnhbPYrxFCLVcopPihFDSEC5Wxbf1BsrPwW17CPdb3YPfOp2gXM_apDIM5blbyi8wQbLJ3kF56WAEn2Jp4y_bGOZpY01pfZly0vUyal9egQ8jPC-eDNpFeHF4T4uvHy7XF9fVzaerjxfnN5VpME6VBIk5EyC0NrjnmDSm6wgzVHDaUM1JRzjpdYcG1rQNyJ5orDEaWpS_IAk9Ld7vc6elG6E3eb1ZOzXNdtTzVgVt1d-Ktxv1PdwpTiXG2f5mbw8xWRWNTWA2JngPJqmGsJYznqGzw4w5_FggJjXaaMA57SEsUYlWEErb_4OYc8koRxms96CZQ4wzDA8LY6R2zapds0oKJdWu2Wx4fXzmA36oMutvD7qORrth1t7Y-Ce1ZUgQ1hzl7PJ_y8dzzv6lq2FxLsF9yuCrPXgbU5iP9uF5UkN_AsFazbo</recordid><startdate>19900401</startdate><enddate>19900401</enddate><creator>Economou, Effrosini P.</creator><creator>Bergen, Andrew W.</creator><creator>Warren, Andrew C.</creator><creator>Antonarakis, Stylianos E.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19900401</creationdate><title>The Polydeoxyadenylate Tract of Alu Repetitive Elements is Polymorphic in the Human Genome</title><author>Economou, Effrosini P. ; Bergen, Andrew W. ; Warren, Andrew C. ; Antonarakis, Stylianos E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-8e81547e7aac1d5126cbb24c375363a52b252dab0f4696e8d2a1a10f908d2e823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>550401 - Genetics- Tracer Techniques</topic><topic>Alleles</topic><topic>ANIMALS</topic><topic>Base Sequence</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MARKERS</topic><topic>Chromosome polymorphism</topic><topic>Chromosomes</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DNA</topic><topic>DNA SEQUENCING</topic><topic>ENZYMES</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE AMPLIFICATION</topic><topic>Genes</topic><topic>Genetic polymorphism</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genome, Human</topic><topic>GLOBINS</topic><topic>Human</topic><topic>Human genome</topic><topic>Humans</topic><topic>ISOTOPES</topic><topic>LIGHT NUCLEI</topic><topic>LYASES</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>Molecular Sequence Data</topic><topic>NUCLEI</topic><topic>Nucleotides</topic><topic>ODD-ODD NUCLEI</topic><topic>Oligonucleotide Probes</topic><topic>Oligonucleotides</topic><topic>ORGANIC COMPOUNDS</topic><topic>Pedigree</topic><topic>PHOSPHORUS 32</topic><topic>PHOSPHORUS ISOTOPES</topic><topic>Poly A - genetics</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Genetic</topic><topic>PRIMATES</topic><topic>PROTEINS</topic><topic>RADIOISOTOPES</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>RFLPS</topic><topic>STRUCTURAL CHEMICAL ANALYSIS</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Economou, Effrosini P.</creatorcontrib><creatorcontrib>Bergen, Andrew W.</creatorcontrib><creatorcontrib>Warren, Andrew C.</creatorcontrib><creatorcontrib>Antonarakis, Stylianos E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Economou, Effrosini P.</au><au>Bergen, Andrew W.</au><au>Warren, Andrew C.</au><au>Antonarakis, Stylianos E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Polydeoxyadenylate Tract of Alu Repetitive Elements is Polymorphic in the Human Genome</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1990-04-01</date><risdate>1990</risdate><volume>87</volume><issue>8</issue><spage>2951</spage><epage>2954</epage><pages>2951-2954</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3' ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the β-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2326257</pmid><doi>10.1073/pnas.87.8.2951</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1990-04, Vol.87 (8), p.2951-2954 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_53811 |
| source | Open Access: PubMed Central; JSTOR Archival Journals and Primary Sources Collection |
| subjects | 550201 - Biochemistry- Tracer Techniques 550401 - Genetics- Tracer Techniques Alleles ANIMALS Base Sequence BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL MARKERS Chromosome polymorphism Chromosomes Classical genetics, quantitative genetics, hybrids DAYS LIVING RADIOISOTOPES DNA DNA SEQUENCING ENZYMES Female Fundamental and applied biological sciences. Psychology GENE AMPLIFICATION Genes Genetic polymorphism Genetics of eukaryotes. Biological and molecular evolution Genome, Human GLOBINS Human Human genome Humans ISOTOPES LIGHT NUCLEI LYASES Male MAMMALS MAN Molecular Sequence Data NUCLEI Nucleotides ODD-ODD NUCLEI Oligonucleotide Probes Oligonucleotides ORGANIC COMPOUNDS Pedigree PHOSPHORUS 32 PHOSPHORUS ISOTOPES Poly A - genetics Polymerase chain reaction Polymorphism, Genetic PRIMATES PROTEINS RADIOISOTOPES Repetitive Sequences, Nucleic Acid RFLPS STRUCTURAL CHEMICAL ANALYSIS VERTEBRATES |
| title | The Polydeoxyadenylate Tract of Alu Repetitive Elements is Polymorphic in the Human Genome |
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