Cerebral haemodynamics during experimental intracranial hypertension

Intracranial hypertension is a common final pathway in many acute neurological conditions. However, the cerebral haemodynamic response to acute intracranial hypertension is poorly understood. We assessed cerebral haemodynamics (arterial blood pressure, intracranial pressure, laser Doppler flowmetry,...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2017-02, Vol.37 (2), p.694-705
Main Authors: Donnelly, Joseph, Czosnyka, Marek, Harland, Spencer, Varsos, Georgios V, Cardim, Danilo, Robba, Chiara, Liu, Xiuyun, Ainslie, Philip N, Smielewski, Peter
Format: Article
Language:English
Subjects:
Animals
Blood Flow Velocity
Blood Pressure
Brain - blood supply
Brain - diagnostic imaging
Cerebrovascular Circulation
Female
Hemodynamics
Intracranial Hypertension - blood
Intracranial Hypertension - diagnostic imaging
Intracranial Pressure
Male
Original
Rabbits
Ultrasonography, Doppler, Transcranial
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Summary:Intracranial hypertension is a common final pathway in many acute neurological conditions. However, the cerebral haemodynamic response to acute intracranial hypertension is poorly understood. We assessed cerebral haemodynamics (arterial blood pressure, intracranial pressure, laser Doppler flowmetry, basilar artery Doppler flow velocity, and vascular wall tension) in 27 basilar artery-dependent rabbits during experimental (artificial CSF infusion) intracranial hypertension. From baseline (∼9 mmHg; SE 1.5) to moderate intracranial pressure (∼41 mmHg; SE 2.2), mean flow velocity remained unchanged (47 to 45 cm/s; p = 0.38), arterial blood pressure increased (88.8 to 94.2 mmHg; p 
ISSN:0271-678X
1559-7016
DOI:10.1177/0271678X16639060