Experimental Validation of Antidiabetic Potential of Cayratia trifolia (L.) Domin: An Indigenous Medicinal Plant

The present study was undertaken to evaluate antidiabetic and antioxidant activities of Cayratia trifolia root extract against streptozotocin induced diabetes in experimental rats to scientifically validate its use against diabetes in some parts of India. Ethanolic extract, showing the highest activ...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2017-06, Vol.32 (2), p.153-162
Main Authors: Mohammed, Shahid Iqbal, Salunkhe, Narendra Subhash, Vishwakarma, Kishor Sukhlal, Maheshwari, Vijay Laxminarayan
Format: Article
Language:English
Subjects:
Antioxidants
Biochemistry
Biomedical and Life Sciences
Blood sugar
Chemistry/Food Science
Chromatography
Diabetes
Diabetes therapy
Glycogen
Herbal medicine
Hypoglycemia
Life Sciences
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Metabolites
Metronidazole
Microbiology
Original
Original Article
Pathology
Sterols
Streptozocin
Type 2 diabetes
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Summary:The present study was undertaken to evaluate antidiabetic and antioxidant activities of Cayratia trifolia root extract against streptozotocin induced diabetes in experimental rats to scientifically validate its use against diabetes in some parts of India. Ethanolic extract, showing the highest activity in in vitro experiments, was prepared in saline and administered orally to streptozotocin induced albino Wistar diabetic rats for 21 days. Biochemical parameters liver and muscles glycogen and in vivo antioxidant activity in normal, diabetic control, standard (metformin) and treated animals were determined and compared. Attempt was made to isolate, purify and characterize one of the major secondary metabolites in extract by range of chromatographic and spectroscopic techniques. Treatment of streptozotocin induced diabetic rats with ethanolic root extract (500 mg/kg) caused significant ( P  
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-016-0598-1