Cytokines: roles in atherosclerosis disease progression and potential therapeutic targets

Atherosclerosis, the primary cause of cardiovascular disease (CVD), is a chronic inflammatory disorder in the walls of medium and large arteries. CVD is currently responsible for about one in three global deaths and this is expected to rise in the future due to an increase in the prevalence of obesi...

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Bibliographic Details
Published in:Future medicinal chemistry 2016-07, Vol.8 (11), p.1317-1330
Main Authors: Moss, Joe WE, Ramji, Dipak P
Format: Article
Language:English
Subjects:
atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - metabolism
Atherosclerosis - pathology
cardiovascular disease
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - metabolism
chemokines
cytokines
Cytokines - metabolism
Disease Progression
foam cells
Humans
inflammation
Inflammation - drug therapy
Inflammation - metabolism
nanoparticles
neutralization
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Summary:Atherosclerosis, the primary cause of cardiovascular disease (CVD), is a chronic inflammatory disorder in the walls of medium and large arteries. CVD is currently responsible for about one in three global deaths and this is expected to rise in the future due to an increase in the prevalence of obesity and diabetes. Current therapies for atherosclerosis mainly modulate lipid homeostasis and while successful at reducing the risk of a CVD-related death, they are associated with considerable residual risk and various side effects. There is, therefore, a need for alternative therapies aimed at regulating inflammation in order to reduce atherogenesis. This review will highlight the key role cytokines play during disease progression as well as potential therapeutic strategies to target them.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2016-0072