Metacognitive ability correlates with hippocampal and prefrontal microstructure

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2017-04, Vol.149, p.415-423
• Main Authors: Allen, Micah, Glen, James C., Müllensiefen, Daniel, Schwarzkopf, Dietrich Samuel, Fardo, Francesca, Frank, Darya, Callaghan, Martina F., Rees, Geraint
• Format: Article
• Language: English
• Subjects: Adult; Brain; Brain mapping; Brain Mapping - methods; Brain research; Cortex (parietal); Decision making; Female; High resolution; Hippocampus; Hippocampus - physiology; Histology; Humans; Image Interpretation, Computer-Assisted - methods; Iron; Magnetic Resonance Imaging - methods; Male; Medical imaging; Memory; Metacognition; Metacognition - physiology; Microstructure; Morphology; Myelination; Nerve Fibers, Myelinated - physiology; Neurobiology; Neuroimaging; Neurology; Neurosciences; Prefrontal cortex; Prefrontal Cortex - physiology; Quantitative MRI; Substantia grisea; University colleges; Visual cortex; Visual perception; Young Adult
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2017.02.008

The ability to introspectively evaluate our experiences to form accurate metacognitive beliefs, or insight, is an essential component of decision-making. Previous research suggests individuals vary substantially in their level of insight, and that this variation is related to brain volume and function, particularly in the anterior prefrontal cortex (aPFC). However, the neurobiological mechanisms underlying these effects are unclear, as qualitative, macroscopic measures such as brain volume can be related to a variety of microstructural features. Here we leverage a high-resolution (800µm isotropic) multi-parameter mapping technique in 48 healthy individuals to delineate quantitative markers of in vivo histological features underlying metacognitive ability. Specifically, we examined how neuroimaging markers of local grey matter myelination and iron content relate to insight as measured by a signal-theoretic model of subjective confidence. Our results revealed a pattern of microstructural correlates of perceptual metacognition in the aPFC, precuneus, hippocampus, and visual cortices. In particular, we extend previous volumetric findings to show that right aPFC myeloarchitecture positively relates to metacognitive insight. In contrast, decreased myelination in the left hippocampus correlated with better metacognitive insight. These results highlight the ability of quantitative neuroimaging to reveal novel brain-behaviour correlates and may motivate future research on their environmental and developmental underpinnings. •Metacognitive ability (insight) differs strongly between individuals.•We used quantitative MRI to relate metacognition to brain microstructure.•Insight correlated positively with anterior prefrontal myelination.•Myelination of the left hippocampus negatively related to insight.•Iron levels in the visual cortex were negatively associated with metacognition.