Differences in Immunologic Factors Among Patients Presenting with Altered Mental Status During Cryptococcal Meningitis

Altered mental status in cryptococcal meningitis results in poorer survival, but underlying causes of altered mentation are poorly understood. Within two clinical trials, we assessed risk factors for altered mental status (GCS score

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Bibliographic Details
Published in:The Journal of infectious diseases 2017-03, Vol.215 (5), p.693-697
Main Authors: Lofgren, Sarah, Hullsiek, Kathy H., Morawski, Bozena M., Nabeta, Henry W., Kiggundu, Reuben, Taseera, Kabanda, Musubire, Abdu, Schutz, Charlotte, Abassi, Mahsa, Bahr, Nathan C., Tugume, Lillian, Muzoora, Conrad, Williams, Darlisha A., Rolfes, Melissa A., Velamakanni, Sruti S., Rajasingham, Radha, Meintjes, Graeme, Rhein, Joshua, Meya, David B., Boulware, David R.
Format: Article
Language:English
Subjects:
Adult
Antifungal Agents - therapeutic use
Antigens, Fungal - blood
Brief Report
Chemokine CCL3 - blood
Chemokines - blood
Cryptococcus neoformans
Cytokines - blood
Female
HIV/AIDS
Humans
Interleukin-10 - blood
Male
Meningitis, Cryptococcal - blood
Meningitis, Cryptococcal - drug therapy
Meningitis, Cryptococcal - immunology
Mental Disorders - blood
Mental Disorders - immunology
Pilot Projects
Proportional Hazards Models
Prospective Studies
Risk Factors
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Description
Summary:Altered mental status in cryptococcal meningitis results in poorer survival, but underlying causes of altered mentation are poorly understood. Within two clinical trials, we assessed risk factors for altered mental status (GCS score
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jix033