Anion Recognition as a Supramolecular Switch of Cell Internalization

The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane....

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Bibliographic Details
Published in:Journal of the American Chemical Society 2017-01, Vol.139 (1), p.55-58
Main Authors: Rodríguez, Jéssica, Mosquera, Jesús, Couceiro, José R, Nitschke, Jonathan R, Vázquez, M. Eugenio, Mascareñas, José L
Format: Article
Language:English
Subjects:
Animals
Anions - chemistry
Cell Membrane - chemistry
Chlorocebus aethiops
Macromolecular Substances - chemistry
Molecular Structure
Vero Cells
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Summary:The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.6b11103