GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci

Understanding the interaction between humans and mosquitoes is a critical area of study due to the phenomenal burdens on public health from mosquito-transmitted diseases. In this study, we conducted the first genome-wide association studies (GWAS) of self-reported mosquito bite reaction size (n = 84...

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Bibliographic Details
Published in:Human molecular genetics 2017-04, Vol.26 (7), p.1391-1406
Main Authors: Jones, Amy V, Tilley, Mera, Gutteridge, Alex, Hyde, Craig, Nagle, Michael, Ziemek, Daniel, Gorman, Donal, Fauman, Eric B, Chen, Xing, Miller, Melissa R, Tian, Chao, Hu, Youna, Hinds, David A, Cox, Peter, Scollen, Serena
Format: Article
Language:English
Subjects:
Animals
Association Studies
Culicidae - genetics
Culicidae - pathogenicity
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Insect Bites and Stings - genetics
Insect Bites and Stings - pathology
Phenotype
Polymorphism, Single Nucleotide - genetics
Pruritus - genetics
Pruritus - pathology
Self Report
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:Understanding the interaction between humans and mosquitoes is a critical area of study due to the phenomenal burdens on public health from mosquito-transmitted diseases. In this study, we conducted the first genome-wide association studies (GWAS) of self-reported mosquito bite reaction size (n = 84,724), itchiness caused by bites (n = 69,057), and perceived attractiveness to mosquitoes (n = 16,576). In total, 15 independent significant (P 
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddx036