Associations of Accelerometer-Measured and Self-Reported Sedentary Time With Leukocyte Telomere Length in Older Women

Few studies have assessed the association of sedentary time with leukocyte telomere length (LTL). In a cross-sectional study conducted in 2012-2013, we examined associations of accelerometer-measured and self-reported sedentary time with LTL in a sample of 1,481 older white and African-American wome...

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Bibliographic Details
Published in:American journal of epidemiology 2017-02, Vol.185 (3), p.172-184
Main Authors: Shadyab, Aladdin H, Macera, Caroline A, Shaffer, Richard A, Jain, Sonia, Gallo, Linda C, LaMonte, Michael J, Reiner, Alexander P, Kooperberg, Charles, Carty, Cara L, Di, Chongzhi, Manini, Todd M, Hou, Lifang, LaCroix, Andrea Z
Format: Article
Language:English
Subjects:
Accelerometry
African Americans
Aged
Aged, 80 and over
Cross-Sectional Studies
European Continental Ancestry Group
Exercise - physiology
Female
Humans
Leukocytes - ultrastructure
Middle Aged
Original Contributions
Sedentary Lifestyle
Self Report
Telomere - ultrastructure
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Summary:Few studies have assessed the association of sedentary time with leukocyte telomere length (LTL). In a cross-sectional study conducted in 2012-2013, we examined associations of accelerometer-measured and self-reported sedentary time with LTL in a sample of 1,481 older white and African-American women from the Women's Health Initiative and determined whether associations varied by level of moderate- to vigorous-intensity physical activity (MVPA). The association between sedentary time and LTL was evaluated using multiple linear regression models. Women were aged 79.2 (standard deviation, 6.7) years, on average. Self-reported sedentary time was not associated with LTL. In a model adjusting for demographic characteristics, lifestyle behaviors, and health-related factors, among women at or below the median level of accelerometer-measured MVPA, those in the highest quartile of accelerometer-measured sedentary time had significantly shorter LTL than those in the lowest quartile, with an average difference of 170 base pairs (95% confidence interval: 4, 340). Accelerometer-measured sedentary time was not associated with LTL in women above the median level of MVPA. Findings suggest that, on the basis of accelerometer measurements, higher sedentary time may be associated with shorter LTL among less physically active women.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kww196