Addressing Common Questions Encountered in the Diagnosis and Management of Cardiac Amyloidosis

Advances in cardiac imaging have resulted in greater recognition of cardiac amyloidosis in everyday clinical practice, but the diagnosis continues to be made in patients with late-stage disease, suggesting that more needs to be done to improve awareness of its clinical manifestations and the potenti...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2017-04, Vol.135 (14), p.1357-1377
Main Authors: Maurer, Mathew S, Elliott, Perry, Comenzo, Raymond, Semigran, Marc, Rapezzi, Claudio
Format: Article
Language:English
Subjects:
Aged
Amyloidosis - diagnosis
Amyloidosis - therapy
Cardiomyopathies - diagnosis
Cardiomyopathies - therapy
Humans
Middle Aged
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Advances in cardiac imaging have resulted in greater recognition of cardiac amyloidosis in everyday clinical practice, but the diagnosis continues to be made in patients with late-stage disease, suggesting that more needs to be done to improve awareness of its clinical manifestations and the potential of therapeutic intervention to improve prognosis. Light chain cardiac amyloidosis, in particular, if recognized early and treated with targeted plasma cell therapy, can be managed very effectively. For patients with transthyretin amyloidosis, there are numerous therapies that are currently in late-phase clinical trials. In this review, we address common questions encountered in clinical practice regarding etiology, clinical presentation, diagnosis, and management of cardiac amyloidosis, focusing on recent important developments in cardiac imaging and biochemical diagnosis. The aim is to show how a systematic approach to the evaluation of suspected cardiac amyloidosis can impact the prognosis of patients in the modern era.
ISSN:0009-7322
1524-4539
DOI:10.1161/circulationaha.116.024438