A new player in interstitial cystitis/bladder pain syndrome: platelet‐activating factor – PAF and its connection to smoking

The manuscript “Cigarette Smoke‐Induced Urothelial Cell Damage: Potential Role of Platelet‐Activating Factor” by Kispert et al., identifies a pathway by which smoking could lead to alterations in urothelial cells consistent with those observed in the bladders of IC/BPS patients. [...]it raises the p...

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Bibliographic Details
Published in:Physiological reports 2017-04, Vol.5 (7), p.e13235-n/a
Main Author: Kullmann, Florenta Aura
Format: Article
Language:English
Subjects:
Asthma
Bladder
Cell growth
Chronic illnesses
Cigarettes
Cystitis
Enzymes
Pain
Physiology
Platelet-activating factor
Regulatory Pathways
Renal Conditions, Disorders and Treatments
Signalling Pathways
Smoking
Toxins, Pollutants and Chemical Agents
Ulcers
Urinary bladder
Wound healing
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Summary:The manuscript “Cigarette Smoke‐Induced Urothelial Cell Damage: Potential Role of Platelet‐Activating Factor” by Kispert et al., identifies a pathway by which smoking could lead to alterations in urothelial cells consistent with those observed in the bladders of IC/BPS patients. [...]it raises the possibility that this pathway is dysregulated in the urothelium of IC/BPS patients, regardless of smoking status, thus providing opportunities for new therapies. [...]PAF has been implicated in a number of pathologies associated with chronic inflammation, including asthma, rheumatoid arthritis, inflammatory bowel diseases, and others (Nassif et al. ; Kasperska‐Zajac et al. ; Yost et al. ). [...]can PAF and/or associated pathways be used as biomarkers for diagnosis of IC/BPS and/or for determining whether a specific treatment has a positive effect?
ISSN:2051-817X
2051-817X
DOI:10.14814/phy2.13235