Respiratory syncytial virus hospitalization and mortality: Systematic review and meta‐analysis

Summary Background: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. Methods: Systematic literature review and meta‐analysis of published data from 2000 onwards, r...

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Bibliographic Details
Published in:Pediatric pulmonology 2017-04, Vol.52 (4), p.556-569
Main Authors: Stein, Renato T., Bont, Louis J., Zar, Heather, Polack, Fernando P., Park, Caroline, Claxton, Ami, Borok, Gerald, Butylkova, Yekaterina, Wegzyn, Colleen
Format: Article
Language:English
Subjects:
burden
Child
Child Health Services
Child, Preschool
epidemiology
Fatalities
Global Health
Hospitalization - statistics & numerical data
Humans
Incidence
Infant
Infant, Newborn
Meta-analysis
morbidity
Mortality
Pediatrics
preterm
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Virus Infections - mortality
Respiratory Syncytial Viruses - isolation & purification
Review
Reviews
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Summary:Summary Background: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. Methods: Systematic literature review and meta‐analysis of published data from 2000 onwards, reporting on burden of acute respiratory infection (ARI) due to RSV in children. Main outcomes were hospitalization for severe RSV‐ARI and death. Results: Five thousand two hundred and seventy‐four references were identified. Fifty‐five studies were included from 32 countries. The global RSV‐ARI hospitalization estimates, reported per 1,000 children per year (95% Credible Interval (CrI), were 4.37 (2.98, 6.42) among children
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.23570