Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic dise...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-8
Main Authors: Pecks, Ulrich, Schulz, Sören, Hütten, Matthias, Orlikowsky, Thorsten W., Rausch, Tanja K., Norda, Stephen, Göpel, Wolfgang
Format: Article
Language:English
Subjects:
Analysis
Apolipoproteins
Apolipoproteins E - genetics
Biomedical research
Cardiovascular Diseases - genetics
Cardiovascular Diseases - physiopathology
Cohort Studies
Female
Fetal Growth Retardation - genetics
Fetal Growth Retardation - physiopathology
Fetus
Genotype
Growth retardation
Health aspects
Humans
Infant, Extremely Premature - growth & development
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature - growth & development
Infants (Premature)
Polymorphism, Single Nucleotide
Risk Factors
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Summary:Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (≥22+0 and
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/2837027