Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

As a universally common endocrinopathy in women of reproductive age, the polycystic ovarian syndrome is characterized by composite clinical phenotypes reflecting the contributions of reproductive impact of ovarian dysfunction and metabolic abnormalities with widely varying symptoms resulting from in...

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Bibliographic Details
Published in:Oncotarget 2017-03, Vol.8 (13), p.20656-20666
Main Authors: Li, Shuxia, Zhu, Dongyi, Duan, Hongmei, Ren, Anran, Glintborg, Dorte, Andersen, Marianne, Skov, Vibe, Thomassen, Mads, Kruse, Torben, Tan, Qihua
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group - genetics
DNA Methylation - genetics
Female
Gene Expression Profiling
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Humans
Polycystic Ovary Syndrome - genetics
Research Paper
Transcriptome
Young Adult
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Summary:As a universally common endocrinopathy in women of reproductive age, the polycystic ovarian syndrome is characterized by composite clinical phenotypes reflecting the contributions of reproductive impact of ovarian dysfunction and metabolic abnormalities with widely varying symptoms resulting from interference of the genome with the environment through integrative biological mechanisms including epigenetics. We have performed a genome-wide DNA methylation analysis on polycystic ovarian syndrome and identified a substantial number of genomic sites differentially methylated in the whole blood of PCOS patients and healthy controls (52 sites, false discovery rate < 0.05 and corresponding p value < 5.68e-06), highly consistently replicating biological pathways extensively implicated in immunity and immunity-related inflammatory disorders (false discovery rate < 0.05) that were reportedly regulated in the DNA methylome from ovarian tissue under PCOS condition. Most importantly, our genome-wide profiling focusing on PCOS patients revealed a large number of DNA methylation sites and their enriched functional pathways significantly associated with diverse clinical features (levels of prolactin, estradiol, progesterone and menstrual cycle) that could serve as novel molecular basis of the clinical heterogeneity observed in PCOS women.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.9327