Advanced glycation end products in idiopathic frozen shoulders

Background The pathophysiologic mechanisms behind proliferation of fibroblasts and deposition of dense collagen matrix in idiopathic frozen shoulder remain unclear. Accumulation of advanced glycation end products (AGEs) with cross-linking and stabilization of collagen has been hypothesized to contri...

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Bibliographic Details
Published in:Journal of shoulder and elbow surgery 2016-06, Vol.25 (6), p.981-988
Main Authors: Hwang, Kyu Rim, Murrell, George A.C., MD, DPhil, Millar, Neal L., PhD, FRCSEd (Tr&Ortho), Bonar, Fiona, MBBCh, FRCPath, Lam, Patrick, PhD, Walton, Judie R., PhD
Format: Article
Language:English
Subjects:
adhesive capsulitis
Adipocytes
Adolescent
Adult
advanced glycation end products
Aged
Bursitis - metabolism
Bursitis - pathology
Bursitis - physiopathology
Case-Control Studies
Cell Count
Cell Proliferation
Female
fibroblastic proliferation
Fibroblasts - physiology
Frozen shoulder
Glycation End Products, Advanced - immunology
Glycation End Products, Advanced - metabolism
Humans
Immunohistochemistry
immunoreactivity
Joint Instability - metabolism
Male
Middle Aged
Orthopedics
Prospective Studies
Range of Motion, Articular
Rotator Cuff Injuries - metabolism
Rotator Cuff Injuries - physiopathology
Shoulder Joint - metabolism
Shoulder Joint - physiopathology
Shoulder Pain - etiology
stiff shoulder
Young Adult
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Summary:Background The pathophysiologic mechanisms behind proliferation of fibroblasts and deposition of dense collagen matrix in idiopathic frozen shoulder remain unclear. Accumulation of advanced glycation end products (AGEs) with cross-linking and stabilization of collagen has been hypothesized to contribute to this pathophysiologic process. This study investigated whether the immunoreactivity of AGEs is higher in patients with idiopathic frozen shoulder than in the control groups. Methods Shoulder capsule samples were collected from 8 patients with idiopathic frozen shoulder, 6 with unstable shoulders (control 1), and 8 with rotator cuff tears (control 2). The samples were hematoxylin and eosin stained and analyzed by immunohistochemistry using antibodies against AGEs. Immunoreactivities were rated in a blinded fashion from none (0) to strong (3). Immunohistochemical distribution within the capsule was noted. Results Frozen shoulder patients had greater frequency and severity of self-reported pain ( P  = .02) than rotator cuff tear patients and more restricted range of motion in all planes ( P  
ISSN:1058-2746
1532-6500
DOI:10.1016/j.jse.2015.10.015