Synchronous and bilateral oncocytic carcinoma of the breast: A case report and review of the literature

Synchronous bilateral breast cancer is rare, and oncocytic carcinoma is an even rarer breast cancer histological subtype. In general, oncocytic tumors are defined as neoplasms with eosinophilic granular cytoplasm and have been reported in various organs. Oncocytic carcinoma of the breast was first d...

Full description

Saved in:
Bibliographic Details
Published in:Oncology letters 2017-03, Vol.13 (3), p.1714-1718
Main Authors: Itagaki, Hiroko, Yamamoto, Tomoko, Hiroi, Atsuko, Kawanishi, Kunio, Noguchi, Eiichiro, Ohchi, Tetsuya, Kamio, Takako, Kameoka, Shingo, Oda, Hideaki, Nagashima, Yoji
Format: Article
Language:English
Subjects:
Antigens
Breast cancer
Breasts
Cancer therapies
Care and treatment
Case reports
Case studies
Colorectal cancer
Cytoplasm
Diagnosis
Endocrine system
Epidermal growth factor
Family medical history
Immunoglobulins
Metastasis
Microscopy
Mitochondria
Mitochondrial DNA
Mutation
Pituitary gland
Radiation therapy
Thyroid gland
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Synchronous bilateral breast cancer is rare, and oncocytic carcinoma is an even rarer breast cancer histological subtype. In general, oncocytic tumors are defined as neoplasms with eosinophilic granular cytoplasm and have been reported in various organs. Oncocytic carcinoma of the breast was first documented by Gădăleanu and Craciun in 1987, and 48 cases have since been reported. The present study reports a case of synchronous bilateral breast oncocytic carcinoma. The patient was a 78-year-old woman. Although she exhibited no symptoms, chest computed tomography revealed three multinodular breast tumors: Two in the right breast and one in the left. Core needle biopsy was performed on the three tumors, and the patient was diagnosed with invasive ductal carcinoma with potential apocrine carcinoma. A bilateral modified radical mastectomy was performed. Surgical specimens of the three tumors revealed cord- or nest-forming tumor cells with eosinophilic granular cytoplasm. Immunohistochemically, the tumor cells were markedly positive for mitochondria. Electron microscopy of the tumor samples additionally revealed numerous mitochondria filling the cytoplasm. Based on these findings, the tumors were diagnosed as oncocytic carcinoma. The pathogenesis of oncocytic carcinoma remains to be fully elucidated; thus, additional clinicopathological studies are required.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.5610