Complex multifractal nature in Mycobacterium tuberculosis genome

The mutifractal and long range correlation ( C(r )) properties of strings, such as nucleotide sequence can be a useful parameter for identification of underlying patterns and variations. In this study C(r ) and multifractal singularity function f(α ) have been used to study variations in the genomes...

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Published in:Scientific reports 2017-04, Vol.7 (1), p.46395-46395, Article 46395
Main Authors: Mandal, Saurav, Roychowdhury, Tanmoy, Chirom, Keilash, Bhattacharya, Alok, Brojen Singh, R. K.
Format: Article
Language:English
Subjects:
45/23
631/114/2397
631/57/2266
639/705/1042
Drug resistance
Genomes
Humanities and Social Sciences
multidisciplinary
Multidrug resistance
Nucleotide sequence
Scaling
Science
Tuberculosis
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Summary:The mutifractal and long range correlation ( C(r )) properties of strings, such as nucleotide sequence can be a useful parameter for identification of underlying patterns and variations. In this study C(r ) and multifractal singularity function f(α ) have been used to study variations in the genomes of a pathogenic bacteria Mycobacterium tuberculosis . Genomic sequences of M. tuberculosis isolates displayed significant variations in C(r ) and f(α ) reflecting inherent differences in sequences among isolates. M. tuberculosis isolates can be categorised into different subgroups based on sensitivity to drugs, these are DS (drug sensitive isolates), MDR (multi-drug resistant isolates) and XDR (extremely drug resistant isolates). C(r ) follows significantly different scaling rules in different subgroups of isolates, but all the isolates follow one parameter scaling law. The richness in complexity of each subgroup can be quantified by the measures of multifractal parameters displaying a pattern in which XDR isolates have highest value and lowest for drug sensitive isolates. Therefore C(r ) and multifractal functions can be useful parameters for analysis of genomic sequences.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep46395