Association Between Frailty and Components of the Frailty Phenotype With Modifiable Risk Factors and Antiretroviral Therapy

The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV)–infected adults has not been well described. HIV-infected participants aged ≥40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessme...

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Bibliographic Details
Published in:The Journal of infectious diseases 2017-03, Vol.215 (6), p.933-937
Main Authors: Erlandson, Kristine M., Wu, Kunling, Koletar, Susan L, Kalayjian, Robert C., Ellis, Ronald J., Taiwo, Babafemi, Palella, Frank J, Tassiopoulos, Katherine
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antiretroviral Therapy, Highly Active
Brief Report
Female
Frail Elderly - statistics & numerical data
HIV Infections - drug therapy
HIV/AIDS
Humans
Logistic Models
Male
Middle Aged
Phenotype
Risk Factors
United States
Walking Speed
Weight Loss
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Summary:The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV)–infected adults has not been well described. HIV-infected participants aged ≥40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 participants, 6% were frail, and 38% were prefrail. Frailty was associated with lower education, older age, Medicare/Medicaid, initial efavirenz, smoking, obesity, and neurocognitive impairment; physical activity and alcohol use were protective. The associations with ART require further investigation, and associations between frailty and modifiable factors provide targets for future interventions.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jix063