Textural analysis of multiparametric MRI detects transition zone prostate cancer

Objectives To evaluate multiparametric-MRI (mpMRI) derived histogram textural-analysis parameters for detection of transition zone (TZ) prostatic tumour. Methods Sixty-seven consecutive men with suspected prostate cancer underwent 1.5T mpMRI prior to template-mapping-biopsy (TPM). Twenty-six men had...

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Bibliographic Details
Published in:European radiology 2017-06, Vol.27 (6), p.2348-2358
Main Authors: Sidhu, Harbir S., Benigno, Salvatore, Ganeshan, Balaji, Dikaios, Nikos, Johnston, Edward W., Allen, Clare, Kirkham, Alex, Groves, Ashley M., Ahmed, Hashim U., Emberton, Mark, Taylor, Stuart A., Halligan, Steve, Punwani, Shonit
Format: Article
Language:English
Subjects:
Aged
Area Under Curve
Biopsy
Biopsy - methods
Consensus
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging
Entropy
Humans
Imaging
Internal Medicine
Interventional Radiology
Kurtosis
Magnetic Resonance
Magnetic resonance imaging
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Prostate - pathology
Prostate cancer
Prostatic Neoplasms - pathology
Radiology
Retrospective Studies
ROC Curve
Tumors
Ultrasound
University colleges
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Summary:Objectives To evaluate multiparametric-MRI (mpMRI) derived histogram textural-analysis parameters for detection of transition zone (TZ) prostatic tumour. Methods Sixty-seven consecutive men with suspected prostate cancer underwent 1.5T mpMRI prior to template-mapping-biopsy (TPM). Twenty-six men had ‘significant’ TZ tumour. Two radiologists in consensus matched TPM to the single axial slice best depicting tumour, or largest TZ diameter for those with benign histology, to define single-slice whole TZ-regions-of-interest (ROIs). Textural-parameter differences between single-slice whole TZ-ROI containing significant tumour versus benign/insignificant tumour were analysed using Mann Whitney U test. Diagnostic accuracy was assessed by receiver operating characteristic area under curve (ROC-AUC) analysis cross-validated with leave-one-out (LOO) analysis. Results ADC kurtosis was significantly lower (p 
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-016-4579-9