Results of adjuvant radiation therapy for locoregional perihilar cholangiocarcinoma after curative intent resection

This study sought to define the role of adjuvant radiation therapy (RT) for patients with curative intent resection of perihilar cholangiocarcinoma (pCCA). By using the Surveillance, Epidemiology and End Results (SEER) registry, 1,917 patients with non-metastatic pCCA who underwent surgical resectio...

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Bibliographic Details
Published in:OncoTargets and therapy 2017-01, Vol.10, p.2257-2266
Main Authors: Leng, Kai-Ming, Liu, Yue-Ping, Wang, Zhi-Dong, Zhong, Xiang-Yu, Liao, Guan-Qun, Kang, Peng-Cheng, Cui, Yun-Fu, Jiang, Xing-Ming
Format: Article
Language:English
Subjects:
Bias
Bile
Biliary tract cancer
Cancer therapies
Care and treatment
Disease
Epidemiology
Hospitals
Medical prognosis
Metastasis
Original Research
Patient outcomes
Patients
Radiation therapy
Radiotherapy
Studies
Surgery
Surveillance
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Summary:This study sought to define the role of adjuvant radiation therapy (RT) for patients with curative intent resection of perihilar cholangiocarcinoma (pCCA). By using the Surveillance, Epidemiology and End Results (SEER) registry, 1,917 patients with non-metastatic pCCA who underwent surgical resection from 1988 to 2009 were included in this study. Propensity score methods were used to compare the survival outcomes of patients treated with and without adjuvant RT after controlling for selection bias. Of the 1,917 patients, 762 (39.7%) received adjuvant RT. In the unmatched population, median overall survival (OS) for patients receiving adjuvant RT compared with those undergoing surgery alone was 23 versus 22 months ( =0.651). Patients who received adjuvant RT were younger (65 vs 68 years,
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S131873