Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Several studies were conducted to explore the prognostic significance of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC), however, contradictory results across most reports were documented. To this end, we present a systematic review that aims to summarize the prognostic signifi...

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Bibliographic Details
Published in:Oncotarget 2017-04, Vol.8 (14), p.22854-22862
Main Authors: Zhao, Yongzhao, Si, Guangyan, Zhu, Fengshang, Hui, Jialiang, Cai, Shangli, Huang, Chenshen, Cheng, Sijin, Fathy, Abdel Hamid, Xiang, Yi, Li, Jing
Format: Article
Language:English
Subjects:
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - pathology
Disease-Free Survival
Female
Humans
Liver Neoplasms - blood
Liver Neoplasms - pathology
Lymphocyte Count
Platelet Count
Prognosis
Research Paper
Survival Analysis
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Summary:Several studies were conducted to explore the prognostic significance of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC), however, contradictory results across most reports were documented. To this end, we present a systematic review that aims to summarize the prognostic significance of PLR in patients with HCC. A total of 10 studies involving a total of 2,315 patients were identified. The Newcastle-Ottawa Quality Assessment Scale (NOS) of each included study was greater than or equal to 5. The results indicated that high PLR was significantly associated with a worse OS when compared to the low PLR (HR = 1.60, 95% CI = 1.23-2.08, p = 0.0005; I2 = 88%, p < 0.00001). Similar results were detected in the subgroup analysis of the analysis model, cut-off value, ethnicity, sample size and therapy. However, no obvious correlation between the PLR and DFS/RFS in patients with HCC was observed (HR = 1.21, 95% CI = 0.87-1.67, p = 0.26; I2 = 61%, p = 0.07). A complete literature search in the PubMed, Cochrane Library and Embase database was performed. Retrospective and prospective studies focusing on the role of PLR on the prognosis in HCC were all deemed as "suitable" for our scope. The endpoints determined were: the overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and the progress free survival (PFS). The study revealed that high PLR is an unfavorable predictor of OS in patients with HCC, and high PLR is a promising prognostic biomarker for HCC, especially for patients in Asia.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.15281