COGNITIVE-ENHANCING PROPERTIES OF MORINDA LUCIDA (RUBIACEAE) AND PELTOPHORUM PTEROCARPUM (FABACEAE) IN SCOPOLAMINE-INDUCED AMNESIC MICE

Background: Cognitive disorders associated with aging have been successfully managed by African traditional medical practitioners using various plants. This study evaluated the cognitive enhancing potentials of Morinda lucida (L) Rubiaceae and Peltophorum pterocarpum (DC) ex. K Heyne in scopolamine...

Full description

Saved in:
Bibliographic Details
Published in:African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2017, Vol.14 (3), p.136-141
Main Authors: Elufioye, Taiwo O, Hameed, Halimah A
Format: Article
Language:English
Subjects:
Amnesia - chemically induced
Amnesia - drug therapy
Amnesia - pathology
Animals
Cognition - drug effects
Fabaceae - chemistry
Hippocampus
Hippocampus - drug effects
Hippocampus - pathology
Maze Learning - drug effects
Mice
Morinda - chemistry
Morinda lucida
Morris water maze
Nootropic Agents - pharmacology
Peltophorum pterocarpum
Phytotherapy
Plant Extracts - pharmacology
Scopolamine
Scopolamine Hydrobromide
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Cognitive disorders associated with aging have been successfully managed by African traditional medical practitioners using various plants. This study evaluated the cognitive enhancing potentials of Morinda lucida (L) Rubiaceae and Peltophorum pterocarpum (DC) ex. K Heyne in scopolamine induced amnesic animals. Materials and Methods: The anti-amnesic activity of the ethyl acetate extracts of Morinda lucida and Peltophorum pterocarpum at doses of 4 mg/kg, 6 mg/kg and 8 mg/kg were assessed in scopolamine induced amnesic mice using Morris water maze test model. Effect of the extracts on the histology of the hippocampus was also evaluated. Results: The ethyl acetate extract of Morinda lucida and Peltophorum pterocarpum ameliorated scopolamine induced memory deficit in the animals under study. There was no effect of the extract on the histology of the hippocampus. However, there was an increase in the density of cells in the hippocampus of treated group as compared to the untreated. Conclusion: Morinda lucida and Peltophorum pterocarpum showed considerable enhancement of cognition in scopolamine induced amnesic mice.
ISSN:0189-6016
2505-0044
DOI:10.21010/ajtcam.v14i3.14