Gestational Hyperandrogenism in Developmental Programming

Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. Potential causes of androgen excess in women include: polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity amongst many others. During pregnancy, lu...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2017-02, Vol.158 (2), p.199-212
Main Authors: Hakim, C, Padmanabhan, V, Vyas, AK
Format: Article
Language:English
Subjects:
Androgens
Androgens - physiology
Animals
Aromatase
Biomarkers
Editor's Choice
Endocrine disorders
Endocrinology
Environmental impact
Female
Fetal Development
Fetuses
Humans
Hyperandrogenism - etiology
Hyperplasia
Luteoma
Mini-reviews
Offspring
Pathology
Phenotypes
Placenta
Polycystic ovary syndrome
Pregnancy
Pregnancy Complications - etiology
Programming
Race factors
Tumors
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Summary:Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. Potential causes of androgen excess in women include: polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity amongst many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. This paper reviews the various phenotypes of hyperandrogenism during pregnancy, its origin, pathophysiology, and the impact of hyperandrogenism on fetal developmental trajectory and offspring consequences.
ISSN:0013-7227
1945-7170
DOI:10.1210/en.2016-1801